HPV linked to rare sinonasal cancers in new study
NCT ID NCT04979000
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looked at 49 people with sinonasal cancer to see if high-risk HPV, tobacco, alcohol, or drug use play a role. Researchers tested tumor samples for HPV and compared risk factors by gender and race. The goal is to better understand what causes these rare cancers.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could clarify how HPV and lifestyle factors contribute to sinonasal cancers, potentially guiding future prevention or screening strategies.
- What could go wrong
- This is a small, completed observational study (49 participants) that looks back at existing data, so it cannot prove cause and effect or directly lead to a new treatment.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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49 people
The number who actually took part.
- Started
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Aug 2021
- Finished
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May 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Cases: Patients with a confirmed diagnosis of sinonasal cancer, or clinical findings consistent with this diagnosis, seen in the Departments of Otolaryngology/Head and Neck Surgery, Radiation Oncology, or Medical Oncology of the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center (SKCCC) or Johns Hopkins Head and Neck Surgery at Suburban Hospital are eligible for this study. Controls: Patients seen for benign conditions in the same Departments of Otolaryngology/Head and Neck Surgery, Radiation Oncology, and Medical Oncology at SKCCC or Suburban Hospital are eligible for enrollment as non-cancer controls in this study.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Cases: * Patients must be 18 years of age or older with a confirmed or suspected diagnosis of sinonasal cancer * Patients must have either a routine diagnostic biopsy of primary tumor or surgical resection planned as part of routine care (to allow for the collection of tumor sample for the study) or grant access to archival material, from a previously performed biopsy. * Willing to provide 20 mL blood sample * Ability to understand and the willingness to sign a written informed consent document * Controls: * Must be 18 years of age or older within the categories of age, gender, and race needed to match cases * Ability to understand and the willingness to sign a written informed consent document Exclusion Criteria: * Cases: * Presence of medical or psychiatric condition affecting ability to give voluntary, informed consent * Participants who do not speak English and do not agree to use of a telephone or video interpreter will be excluded. However, if there is a hearing, literally or minor fluency issue and the participant requests assistance from a family member or the study coordinator, this individual may still enroll and receive this assistance to ensure they fully hear and understand everything being asked * Controls: * Presence of medical or psychiatric condition affecting ability to give voluntary, informed consent * Participants who do not speak English and do not agree to use of a telephone or video interpreter will be excluded. However, if there is a hearing, literacy or minor fluency issue and the participant requests assistance from a family member or the study coordinator, this individual may still enroll and receive this assistance to ensure they fully hear and understand everything being asked * No prior diagnosis of head and neck cancer, except basal cell cancer * No previous radiation therapy of the head and neck
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Johns Hopkins University
Baltimore, Maryland, 21287, United States
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