Could a drug combo supercharge immune attack on HPV head and neck cancer?
NCT ID NCT05317000
First seen Nov 01, 2025 · Last updated May 21, 2026 · Updated 24 times
Summary
This study tests whether combining a chemotherapy drug (5-azacytidine) with an immunotherapy drug (nivolumab) can make HPV-related head and neck cancer more sensitive to the immune system. About 50 people with resectable oropharynx cancer will receive one or both drugs before their planned surgery. The goal is to see if the combination leads to a stronger anti-tumor immune response than either drug alone.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Yale University
RECRUITINGNew Haven, Connecticut, 06511, United States
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