Could a drug combo make HPV head and neck cancer more vulnerable?
NCT ID NCT05317000
First seen Nov 01, 2025 · Last updated May 03, 2026 · Updated 22 times
Summary
This study tests whether giving a chemotherapy drug (5-azacytidine) and an immunotherapy drug (nivolumab) together, before surgery, can boost the immune system's attack on HPV-related head and neck cancer. About 50 people with resectable oropharynx cancer will receive one or both drugs for a short time. The goal is to see if the combination works better than either drug alone at shrinking tumors and activating immune cells.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Yale University
RECRUITINGNew Haven, Connecticut, 06511, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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