Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Muscle nerves may hold key to easier breathing and cooling during workouts

NCT ID NCT07452094

Knowledge-focused Sponsor: Northern Arizona University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study at Northern Arizona University will test 15 healthy, active adults to understand how specific nerve signals from muscles (called group III/IV afferents) affect breathing, sweating, and skin blood flow during exercise. Participants will cycle with and without a drug that blocks these signals. The goal is to learn how the body naturally regulates airway resistance and temperature during physical activity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cycling exercise with or without a drug that blocks certain muscle nerve signals
What this could lead to
If successful, this study could reveal how muscles communicate with the brain to regulate breathing and cooling during exercise, potentially guiding future treatments for exercise intolerance.
What could go wrong
This is a very small, early-phase study in healthy volunteers, not patients. The findings may not apply to people with medical conditions, and the drug used to block nerve signals may have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 15 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * regularly physically active as determined via questionnaires (Par-Q \& You) * maximal aerobic power 30 mL/min/kg (female), 40 mL/kg/min (male) Exclusion Criteria: * current smokers * acute bronchial asthma * diabetics * chronic back pain * peripheral neuropathy * chronic obstructive airway or status asthmaticus * obese (body mass index \> 30 kg/m2) * convulsive disorders * requiring daily medications that may affect responses to exercise (e.g. anti-hypertensive, anti-arrhythmogenics, blood thinners) * history of drug abuse * history of disease/dysfunction that could cause complication with exercise (e.g. cardiovascular, respiratory, neurological, musculoskeletal) * irregular or absent menstrual cycle * pregnant or suspected pregnancy * adverse response to physical exercise * current or history of esophageal or gastric disease, or frequent heart burn (\>2x per week) * Lidocaine allergy

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Experimental are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Experimental Placebo - control

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Northern Arizona University

    Flagstaff, Arizona, 86011, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.