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Mountain air on tap: scientists test heart under low oxygen

NCT ID NCT07431567

Knowledge-focused Sponsor: Mona Lichtblau Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how the right side of the heart works when oxygen levels drop, like at high altitudes. Healthy volunteers will breathe special gas mixtures that mimic altitudes of 2,500 and 4,000 meters, both at rest and during light cycling. The goal is to create a baseline for healthy hearts, so doctors can later better support patients with heart or lung conditions who want to exercise in the mountains.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
normobaric hypoxia (simulated altitude via special gas mixture)
What this could lead to
If successful, this study could help doctors better understand how the heart handles low oxygen, potentially improving care for people with heart or lung conditions who travel to high altitudes.
What could go wrong
This is a small, early-stage study in healthy volunteers, not patients. The results may not directly apply to people with heart or lung disease, and the simulated altitude may not fully reflect real mountain conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 18 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2026

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Signed informed consent * 18-80 years (age group young: 18-39.99 years / age group older: 40-80 years) * All sex and genders -Living \<800m and without altitude exposure \> 2500 m and \> 24h within the last three weeks Exclusion Criteria: * \<18, \>80 years old -Any diagnosed cardiopulmonary condition including past HAPE * Other clinically significant severe concomitant disease states (e.g. renal, hepatic dysfunction, etc.) * Inability to follow the procedures of the study due to language problems, psychological neurological disorders or orthopaedic disorders * Participants permanently living \>800m and altitude exposure \> 2500 m and \>24h within the last three weeks * Pregnancy: Participants will be asked if pregnant or not, no screening for undetected pregnancy * Lactating women -Participation in other study with active treatment

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Conditions

The condition(s) this trial relates to.

altitude sickness Dyspnea Hypoxia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Altitude hypoxia Hypoxia Normobaric hypoxia Right heart function

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Consultant Clinic of Pulmonology, University Hospital of Zurich

    RECRUITING

    Zurich, Canton of Zurich, 8091, Switzerland

  • Consultant Clinic of Pulmonology, University Hospital of Zurich

    NOT_YET_RECRUITING

    Zurich, 8091, Switzerland

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