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New study explores hidden health risks after ovary removal

NCT ID NCT07406412

Knowledge-focused Sponsor: University of Jyvaskyla Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 120 women aged 35-50 who are having their ovaries removed (oophorectomy) for non-cancer reasons. Researchers will track changes in quality of life, heart health, brain function, and body fat over one year. Some women may start hormone therapy as part of routine care, and the study will compare outcomes between those who do and those who don't.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal how ovary removal impacts long-term health, guiding better care for women after surgical menopause.
What could go wrong
This is an observational study, not a treatment trial. It cannot prove cause and effect, and results may not apply to all women.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants will be recruited from gynaecological surgical waiting lists at the university and central hospitals across Finland. Recruitment sites include the Wellbeing Service counties of Central Finland, North Savo, Pirkanmaa, Southwest Finland, and North Ostrobothnia, as well as the Hospital District of Helsinki and Uusimaa (HUS).

Ages

35 to 50 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 35-50 years * Pre- or perimenopausal status (defined as self-reported menstrual bleedings and/or follicle-stimulating hormone ≤25 IU/L) * One or two functional ovaries * Planning to undergo bilateral oophorectomy or salpingo-oophorectomy (BSO) or unilateral oophorectomy or salpingo-oophorectomy (SO) if the other ovary has been previously removed, for non-malignant reasons Exclusion Criteria: * Oophorectomy due to ovarian cancer or other malignant conditions * Current systemic estrogen-containing medication The following exclusion criteria apply only to participation in physiological assessments (not questionnaires or interviews): * Severe heart or liver disease * Mobility limitations that prevent participation in physical exercise tests The following factors do not lead to exclusion but will be recorded and considered in analyses: * Use of medications such as weight reduction drugs, lipid-lowering agents, or antihypertensives * Concomitant hysterectomy or other surgeries performed with oophorectomy * Use of local vaginal oestrogen therapy * Initiation of systemic hormone replacement therapy (HRT) after the 1-2-month post-surgery assessments (allowed according to clinical need; not part of the study protocol)

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Conditions

The condition(s) this trial relates to.

Health Behavior premature menopause

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Menopause surgical

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    6 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • HUS

    NOT_YET_RECRUITING

    Helsinki, 00290, Finland

  • University of Jyväskylä

    ACTIVE_NOT_RECRUITING

    Jyväskylä, 40014, Finland

  • Wellbeing Services County of Central Finland

    RECRUITING

    Jyväskylä, 70210, Finland

  • Wellbeing Services County of North Ostrobothnia

    NOT_YET_RECRUITING

    Oulu, 90029, Finland

  • Wellbeing Services County of North Savo

    RECRUITING

    Kuopio, 70210, Finland

  • Wellbeing Services County of Pirkanmaa

    RECRUITING

    Tampere, 33520, Finland

  • Wellbeing Services County of Southwest Finland

    RECRUITING

    Turku, 20520, Finland

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