New hope for kids with rare, Life-Threatening immune storm
NCT ID NCT04551131
Summary
This study is testing a new treatment approach for hemophagocytic lymphohistiocytosis (HLH), a rare and severe immune system disorder. It combines three drugs—ruxolitinib, dexamethasone, and etoposide—in a flexible plan that adjusts based on how each patient responds. The goal is to see if this approach is effective and safe for children and young adults, both for newly diagnosed patients and for those whose disease has returned or not responded to other treatments.
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Contacts and locations
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Locations
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Children's Hospital of Orange County
Orange, California, 92868, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
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Children's Wisconsin/Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Cohen Children's Medical Center
New Hyde Park, New York, 11040, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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John Hopkins University
Baltimore, Maryland, 21287, United States
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Levine Children's Hospital
Charlotte, North Carolina, 28203, United States
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Phoenix Children's Hospital
Phoenix, Arizona, 85016, United States
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St. Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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Texas Children's Hospital
Houston, Texas, 77030, United States
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University of California San Francisco
San Francisco, California, 94158, United States
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University of Texas Southwestern Medical Center
Dallas, Texas, 75235, United States
Conditions
Explore the condition pages connected to this study.