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Scientists investigate rare immune disorder in adults to unlock diagnostic clues

NCT ID NCT02113917

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at 204 adults with hemophagocytic syndrome, a rare immune condition. Researchers aimed to identify biological markers and refine diagnosis criteria, which are currently based on children's genetics. The goal is to better understand the disease's causes in adults.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could lead to better diagnostic criteria and a deeper understanding of hemophagocytic syndrome in adults, potentially guiding future treatments.
What could go wrong
This is an observational study, not a treatment trial. It may not directly lead to new therapies, and findings may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

204 people

The number who actually took part.

Start date

Jan 2010

Finished

Jan 2017

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Infant, Adolescent and adult patients who have a HLH syndrome regardless of etiology, hospitalized in Internal Medicine, Critical Care, Hematology, Rheumatology Neurology or Organ Transplantation

Ages

2 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Major criteria: * hemophagocytosis found in a specimen histology. * Fever * Splenomegaly Minor criteria: * adenopathy * cytopenia\> 2 cell lines Hemoglobin \<9 g / dl (less than 4 weeks and\> 12 g / dl) Platelets \<100 000 x 10 / l Neutrophils \<1 10 / l * hypertriglyceridaemia and / or hypofibrinogenaemia Elevated triglycerides\> 3 mmol / l Fibrinogen \<1.5 g / l * Ferritin\> 500 microg / L These criteria will be those used for the diagnosis of HLH in adults: One major criterion and two minor (including hyper ferritin or hypertriglyceridemia) 3 minor criteria (including hyper ferritin or hypertriglyceridemia) Exclusion Criteria: * Pregnant women * A person under guardianship * Patients under the age of 2 years

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Conditions

The condition(s) this trial relates to.

hemophagocytic syndrome Lymphohistiocytosis, Hemophagocytic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hemophagocytic syndrome

Contacts and locations

Locations

  • Clinical Research Unit

    Paris, 75015, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.