Could early Anti-CMV and TB drugs save HIV-Positive babies with pneumonia?
NCT ID NCT03915366
First seen Nov 01, 2025 · Last updated Jun 14, 2026 · Updated 37 times
Summary
This study looked at whether giving HIV-infected infants (ages 1 month to 1 year) immediate treatment for two common infections—cytomegalovirus (CMV) and tuberculosis (TB)—alongside standard pneumonia care could help them survive. Over 560 babies hospitalized with severe pneumonia were enrolled. The main goal was to see if this approach reduced deaths within 15 days and up to one year.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Cemtro de Investigaçao em Saúde da Manhiça
Manhiça, Mozambique
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Fundación para la Investigación Biomédica del Hospital 12 de Octubre
Madrid, 28041, Spain
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Hospital Central Maputo
Maputo, Mozambique
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INSERM
Toulouse, France
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Lusaka Teaching Hospital
Lusaka, Zambia
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Makerere University - Mulago Hospital
Kampala, Uganda
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Malawi Liverpool Welcome Trust. Queen Elizabeth Central Hospital College of Medicine
Blantyre, Malawi
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PENTA Foundation
Padova, Italy
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Programme PACCI. Centre Hospitalier Cocody.
Abidjan, Côte d’Ivoire
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Stichting Katholieke Universiteit Radboudumc
Nijmegen, Netherlands
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University of Lincoln
Lincoln, United Kingdom
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University of Zimbabwe Clinical Research Centre
Harare, Zimbabwe
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Université de Bourdeaux
Bourdeaux, France
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.