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Could a daily supplement turn back the clock on HIV-Related aging?

NCT ID NCT07462767

Disease control Sponsor: Louisiana State University Health Sciences Center in New Orleans Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether two safe dietary supplements—a probiotic and blueberry extract—can reduce signs of accelerated aging in people with HIV who drink alcohol. Researchers will measure changes in immune cells and biological age markers. The trial involves 160 participants aged 40 and older in a crossover design.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Limosilactobacillus reuteri (probiotic) and blueberry extract
What this could lead to
If it works, this could point toward a simple dietary supplement to slow aging-related immune decline in people with HIV who drink alcohol.
What could go wrong
This is an early Phase 1/2 trial with only 160 participants. The supplements are generally safe, but it is unclear if they will meaningfully change aging markers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 160 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥40 years * People with HIV * Recent alcohol use defined as ≥42 grams in the prior week and positive urine ethyl glucuronide (EtG) Exclusion Criteria: * Probiotic use in past 3 months * Recent antibiotics or immunosuppressives * Allergy to study products * Pregnancy or breastfeeding * Inability to comply

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Conditions

The condition(s) this trial relates to.

Alcohol Drinking HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Alcohol drinking HIV infections Immunosenescence

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • LSU Health

    New Orleans, Louisiana, 70112, United States

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