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Nerve block may offer Opioid-Free pain relief for hip fractures in the ER

NCT ID NCT02381717

Symptom relief Sponsor: Beth Israel Deaconess Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether an ultrasound-guided femoral nerve block (using bupivacaine) works as well as standard opioid painkillers (like morphine) for people with hip fractures in the emergency department. 44 adults with moderate to severe pain were enrolled. The goal was to see if the nerve block could provide similar pain relief without the side effects of opioids.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bupivacaine (nerve block) and morphine (opioid)
What this could lead to
If successful, this could show that a nerve block is as good as or better than opioids for managing hip fracture pain in the ER, potentially reducing opioid use.
What could go wrong
This is a small, completed trial with only 44 participants, so results may not apply to everyone. Nerve blocks carry risks like infection or allergic reaction, though rare.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

44 people

The number who actually took part.

Start date

Aug 2015

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 101 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients over 18 years of age presenting to the ED with radiographically established intra-, extracapsular hip fracture, able to consent and participate in the study and who have moderate to severe pain (numerical pain score \>= 31) at the time of enrollment. Exclusion Criteria: * Patients with a previous history of hypersensitivity to local anesthetics, * Patients who have signs of a local infection at the site of planned needle placement. * INR \> 1.4NOAC use within 48 hours * Prophylactic Low-Molecular Weight Heparin (LMWH) within 12 hours * Therapeutic LMWH within 24 hours * Prophylactic Unfractionated Heparin (5000 Units BID or TID) within 6 hours

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Conditions

The condition(s) this trial relates to.

hip fracture

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hip fracture

Contacts and locations

Locations

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts, 02215, United States

  • St. Vincent's Hospital

    Worcester, Massachusetts, 01608, United States

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