New MRI technique aims to uncover elusive epilepsy triggers
NCT ID NCT06550726
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether high-resolution MRI can find subtle brain lesions that cause focal epilepsy but are missed by standard scans. Researchers will scan 66 adults with drug-resistant epilepsy and compare results to surgical findings. If successful, this could improve diagnosis and help guide surgery for better seizure control.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Magnetic Resonance Imaging (MRI)
- What this could lead to
- If successful, this could make it easier to find hidden brain lesions in people with focal epilepsy, leading to better surgical decisions and possibly seizure control.
- What could go wrong
- This is a small, early-stage study (66 people) focused on diagnosis, not treatment. The advanced MRI may not always find lesions, and results may not apply to all epilepsy patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 66 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2024
- Expected to finish
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Aug 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Consecutive patients with drug-resistant focal epilepsy fulfilling the following criteria - 1\. Diagnosis of focal epilepsy with a probable site identified, as defined by concordant results from any TWO of the following: * Clinical seminology compatible with focal epilepsy. * Electroencephalography pointing towards a specific site for focal epilepsy. * Positive ictal brain scintigraphy with SPECT-CT correlation. AND 2. Previous MRI (at least one study with protocol tailored for epilepsy) which did not reveal accountable focal lesion. AND 3. Able to consent for MRI examination (if patient under age of 18, consent for MRI will be obtained from guardian). Patients will be provided information leaflets to read on, and written consent before taking part in this study and MRI examination. Exclusion Criteria: * Patients who are contraindicated to magnetic resonance imaging (such as due to underlying MRI incompatible metallic implants) * Patients who cannot cooperate for MRI scanning. * Patients show are unable to provide informed consent.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Gerald Choa MRI Center
RECRUITINGHong Kong, Hong Kong
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