New oxygen method could help brain patients breathe easier without a ventilator
NCT ID NCT07257016
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether giving warm, moist oxygen at a high flow rate through a breathing tube is safe and works well for brain-injured patients in the intensive care unit. These patients could breathe on their own but still needed the tube to protect their airway. The goal was to see if this method could help them avoid the risks of staying on a ventilator too long. 24 adults who had brain surgery or injury took part.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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24 people
The number who actually took part.
- Started
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Dec 2025
- Finished
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Apr 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 years. * Post-neurosurgical or brain injury patients with stable intracranial status (Glasgow Coma Scale ≥ 9, Richmond Agitation-Sedation Scale score -2 to +1). * Successful completion of a 30-minute T-piece spontaneous breathing trial (per standard SBT failure criteria). * Poor airway protection capacity (STAGE score \< 6) necessitates ongoing intubation for respiratory support, as determined by the attending physician. * Signed informed consent (by patient or legal representative). Exclusion Criteria: * Contraindications to esophageal pressure monitoring (e.g., esophageal varices, recent esophageal surgery). * History of chronic respiratory diseases (e.g., COPD, severe asthma). * Chronic heart failure (NYHA class III-IV) or severe arrhythmia. * Body Mass Index (BMI) \> 30 kg/m². * Pregnancy. * Anticipated need for tracheostomy without extubation attempt * Withdrawal of life-sustaining treatment
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Capital Medical University Beijing Tiantan Hospital
Beijing, 100070, China
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