Can a High-Fiber diet shield the gut during breast cancer therapy?
NCT ID NCT06610097
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial tests whether personalized nutrition counseling to increase fiber intake can help preserve the diversity of gut microbes in people undergoing treatment for early-stage triple-negative breast cancer. Participants are randomly assigned to receive either coaching from a registered dietitian or an educational handout alone. Researchers will analyze stool samples to see how diet, activity, and mood affect the gut microbiome during neoadjuvant therapy, and whether a high-fiber diet offers a protective effect.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- personalized nutritional counseling with a registered dietitian to increase fiber intake
- What this could lead to
- If a high-fiber diet helps preserve gut microbial diversity during treatment, it could point toward a simple, supportive way to improve outcomes and quality of life for breast cancer patients.
- What could go wrong
- This is a small, early-stage trial, so results may not apply broadly. The intervention is supportive and unlikely to replace standard cancer treatment, and its effect on gut health remains uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Started
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Apr 2025
- Finished
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Aug 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 100 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Diagnosis of early-stage triple-negative breast cancer, not on neoadjuvant systemic therapy at the time of enrollment. * Age greater than or equal to 18 years and less than 100 years * English proficiency at or above 8th grade level * Expected survival greater than or equal to 12 months Exclusion Criteria: * Prebiotic and/or probiotic use prior to and during the study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Scripps Clinic
La Jolla, California, 92037, United States
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