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Butter and bacon for a stronger heart? new trial puts high-fat diet to the test.

NCT ID NCT06747429

Disease control Sponsor: Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a carefully controlled high-fat diet can improve heart function in people with a specific type of heart failure (non-ischemic dilated cardiomyopathy). Researchers believe that switching the heart's fuel source back to fats may help it pump more effectively. The trial will involve 80 adults across four European countries, who will follow the diet for two months while their heart function is monitored with MRI scans.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients of both sexes and ≥18 years old * Patients diagnosed with HF secondary to non-ischemic DCM, according to ESC guidelines definition,1 with or without a known genetic basis. * LVEF ≤49% according to the baseline CMR. * Optimized HF guideline-directed medical therapy for at least 3 months prior to inclusion. * Patients who have provided informed consent. Exclusion Criteria: * Prior diagnosis of ischemic DCM. * Prior diagnosis of established atherosclerotic cardiovascular disease (angina/myocardial infarction, transient ischemic attack/stroke, lower limb ischemia or at any other peripheral level). * Changes in HF therapies within the last 3 months. * HF decompensation within the previous 3 months, including HF hospitalization or the need of ambulatory intravenous diuretic or inotropic treatment such as levosimendan. * Uncontrolled dyslipidemia, defined as LDL-cholesterol \>160 mg/dL and/or triglycerides \>200 mg/dL, despite treatment. * Any contraindication for CMR: Severe claustrophobia. Any device which is known to threaten or pose hazard in all MR environments. //www.mrisafety.com/ Patients with implanted biomedical devices (cardiac artefacts): pacemakers, cardiac defibrillators or cardiac resynchronization therapy. * Liver and biliary diseases, including prior diagnosis of non-alcoholic fatty liver disease and unoperated cholelithiasis. * Prior episodes of acute pancreatitis or chronic pancreatitis. * Prior fish or nut allergy. * Life expectancy less than 12 months. * Pregnancy or planned pregnancy for the next 4 months. * Current lactation. * Patients participating in other randomized clinical trial. * Impossibility to consent or undergo study follow-up

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Conditions

The condition(s) this trial relates to.

dilated cardiomyopathy heart failure non-familial dilated cardiomyopathy systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart failure with reduced ejection fraction Non-ischemic dilated cardiomyopathy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    5 sites in 4 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Fundación Investigación Biomédica Hospital Universitario Puerta de Hierro (IIS),

    RECRUITING

    Madrid, Spain

  • Hospital Universitario Fundación Jiménez Díaz,

    RECRUITING

    Madrid, Spain

  • Hôpital Européen Georges Pompidou, INSERM

    NOT_YET_RECRUITING

    Paris, France

  • University of Florence, Clinical and Experimental Medicine, Unit of Clinical Nutrition,

    NOT_YET_RECRUITING

    Florence, Italy

  • University of Medicine and Pharmacy "Carol Davila", Bucharest,

    RECRUITING

    Bucharest, Romania

More trials for these conditions

Other studies related to the condition(s) this trial covers.