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Could a simple vitamin save lives in the ICU?

NCT ID NCT03188796

Disease control Sponsor: Medical University of Graz Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether giving high doses of vitamin D3 to critically ill patients with very low vitamin D levels can reduce the chance of death within 28 days. The trial will include 2,400 adults in intensive care units. If successful, this cheap and easy treatment could be quickly adopted worldwide.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Vitamin D3 (cholecalciferol)
What this could lead to
If it works, this could provide a simple, inexpensive way to lower death rates in critically ill patients with severe vitamin D deficiency.
What could go wrong
This is a confirmatory trial, but the earlier study was small and the benefit was seen only in a subgroup. There is also a risk of side effects like high calcium levels.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 2,400 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2017

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ≥18 years * Anticipated ICU stay ≥ 48 hours * Admission to ICU ≤ 72 hours before screening * Severe vitamin D deficiency (≤12 ng/ml or undetectable) Exclusion Criteria: * Severe gastrointestinal dysfunction (\> 400 ml residual volume)/unable to take study medication * Do not resuscitate (DNR) order/imminent death * hypercalcemia * known recent nephrolithiasis, active tuberculosis or sarcoidosis * pregnancy/lactation * not deemed appropriate by study team/physician

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Conditions

The condition(s) this trial relates to.

COVID-19 Critical Illness vitamin D deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COVID19 Critical illness Vitamin D deficiency

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    12 sites in 3 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Barmherzige Brüder

    RECRUITING

    Vienna, Austria

  • Barmherzige Schwestern

    RECRUITING

    Linz, Austria

  • CHR Citadelle

    TERMINATED

    Liège, Belgium

  • CHU Ambroise Pare

    TERMINATED

    Mons, Belgium

  • CHU de Charleroi

    TERMINATED

    Charleroi, Belgium

  • Erasme Hospital

    TERMINATED

    Brussels, Belgium

  • Kaiser Franz Josef Spital Wien

    SUSPENDED

    Vienna, Austria

  • Kepler Universitätsklinikum Linz

    RECRUITING

    Linz, Austria

  • Klinikum am Wörthersee

    RECRUITING

    Klagenfurt, Austria

  • Krankenhaus Schwarzach

    TERMINATED

    Schwarzach im Pongau, Austria

  • LKH Enzenbach

    RECRUITING

    Enzenbach, Austria

  • LKH Feldbach

    TERMINATED

    Feldbach, Austria

  • LKH Hochsteiermark Standort Leoben

    RECRUITING

    Leoben, Austria

  • LKH Villach

    RECRUITING

    Villach, Austria

  • Medical University of Graz

    RECRUITING

    Graz, Austria

  • Medical University of Vienna

    RECRUITING

    Vienna, Austria

  • University Hospital Wuerzburg

    RECRUITING

    Würzburg, Germany

  • University of Birmingham

    RECRUITING

    Birmingham, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.