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New drug cocktail aims to wipe out stomach cancer before surgery

NCT ID NCT07477444

First seen Mar 19, 2026 · Last updated May 23, 2026 · Updated 7 times

Summary

This early-phase trial tests whether adding two targeted drugs (zanidatamab and tislelizumab) to standard chemotherapy can completely eliminate HER2-positive gastroesophageal cancer before surgery. About 29 adults with operable, locally advanced cancer will receive the combination before and after tumor removal. The main goals are safety and seeing how many patients have no cancer left at surgery.

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