New hope for kids with liver cancer: tailored chemotherapy trial launches
NCT ID NCT07300449
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing different chemotherapy plans for children with hepatoblastoma, a rare liver cancer. The goal is to find the best treatment for each risk group to improve survival and reduce side effects. The trial will enroll 100 children and teens across 15 hospitals in China.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- chemotherapy (cisplatin, doxorubicin, ifosfamide, carboplatin, etoposide)
- What this could lead to
- If successful, this trial could identify safer and more effective chemotherapy combinations for children with hepatoblastoma, potentially improving survival rates for high-risk cases.
- What could go wrong
- This is a phase 2 trial with a relatively small number of participants, so results may not apply to all patients. Chemotherapy can cause significant side effects, and the intensified regimens may increase toxicity.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jun 2021
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Up to 18 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients with primary hepatoblastoma confirmed by pathology. * The age of the subjects was less than 18 years old. ③ Obtain the informed consent from the guardians and sign the informed consent form Exclusion Criteria: * Recurrent hepatoblastoma or other malignant tumor. * Age\> 18 years old. ③ Patients with other tumors and received chemotherapy and abdominal radiotherapy. * Heart, brain and kidney failure patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Sun Yat-sen University Cancer Center
RECRUITINGGuangzhou, Guangdong, 510060, China
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Sun Yat-sen University Cancer Center
RECRUITINGGuangzhou, Guangdong, 510060, China
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