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Breath monitor could guide surgery care and cut organ failure

NCT ID NCT03852147

Disease control Sponsor: Centre Hospitalier Universitaire, Amiens Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether measuring a patient's exhaled gases during surgery can help doctors better manage fluids and medications. 350 adults having major abdominal, orthopedic, or vascular surgery were randomly assigned to standard care or care guided by the respiratory quotient. The goal was to see if this approach reduces organ failure and death within 30 days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
hemodynamic management algorithm using respiratory quotient measurement
What this could lead to
If successful, this could provide a better way to manage fluids and medications during major surgery, potentially reducing organ failure and complications.
What could go wrong
This is a completed study, but results are not yet widely known. The approach adds complexity and may not improve outcomes over standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

350 people

The number who actually took part.

Started

Dec 2018

Finished

Jan 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Abdominal, orthopedic or vascular surgery with general anesthesia * ASA score ≥ II * Estimated duration of surgery\> 2 hours * Consent signed. * Affiliation to a social security scheme Exclusion Criteria: * Untreated or unbalanced severe hypertension under treatment. * Preoperative renal failure dialyzed. * Acute heart failure. * Acute coronary insufficiency. * Vascular surgery with kidney plasty. * Cardiac surgery. * Permanent laparoscopy. * Preoperative shock state. * Refusal of patient's participation * Pregnant woman, parturient or breastfeeding. * Patient under guardianship or trusteeship, under the protection of justice or private public law. * Anesthesia with loco-regional anesthesia (spinal anesthesia and epidural). * Acute respiratory distress syndrome (PaO2 / FiO2 ratio \<300). * Chronic Respiratory Failure with Home Oxygen Therapy. * Patient already included in another therapeutic trial with an experimental molecule. * Emergency anesthesia

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Conditions

The condition(s) this trial relates to.

Postoperative Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Post-op complication Respiratory complication

Contacts and locations

Locations

  • BAR

    Amiens, 80054, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.