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New embolization technique aims to quiet bleeding hemorrhoids without surgery

NCT ID NCT06106269

Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a procedure called rectal artery embolization (RAE) to treat bleeding from internal hemorrhoids. Doctors use imaging to guide tiny particles into the blood vessels feeding the hemorrhoids, blocking blood flow to reduce bleeding. The trial enrolls 20 adults with grade II or III hemorrhoids who have not improved with diet or medication. Researchers will measure changes in bleeding severity and track any side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
rectal artery embolization (device procedure)
What this could lead to
If successful, this procedure could offer a less invasive option to control bleeding from internal hemorrhoids, potentially reducing the need for surgery.
What could go wrong
This is a small, early-stage trial with only 20 participants. The procedure may not work for everyone, and risks include pain, infection, or bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Subjects referred from the Colon and Rectal Surgery who are scheduled to undergo rectal artery embolization (RAE) as part of their standard clinical care at the Mayo Clinic in Rochester, Minnesota.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Grade II or III hemorrhoidal disease as determined by a board-certified colorectal surgeon. * Persistent or recurrent symptoms following hygiene and dietary measures or medication. * Bleeding predominant ± pain symptoms. * Undergoing planned rectal artery embolization (RAE) per standard clinical care. * Male or female with age greater than 18 years, with the capacity and willingness to provide a written informed consent. * Negative pregnancy test (if applicable). Exclusion Criteria: * Prior hemorrhoid surgery. * Grade IV hemorrhoidal disease. * Acute hemorrhoid complications. * Chronic anal or perianal fissures. * History of colorectal surgery or pelvic radiation. * Inflammatory bowel disease. * Portal hypertension or mesenteric venous congestion/occlusion. * Inferior mesenteric artery (IMA) or internal iliac artery (IIA) stenosis or occlusion. * Contraindication to iodinated contrast. * Pregnant and/or breast-feeding subjects. A negative pregnancy test within 48 hours of the procedure per clinical care.

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Conditions

The condition(s) this trial relates to.

anemia Hemorrhage hemorrhoid internal hemorrhoid

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Internal hemorrhoid

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Mayo Clinic Minnesota

    RECRUITING

    Rochester, Minnesota, 55905, United States

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