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Blood clues may explain why exercise fails some heart patients

NCT ID NCT07164911

Knowledge-focused Sponsor: Centre Hospitalier de Corbie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at why some people with heart failure get better with exercise rehab while others don't. Researchers will measure oxygen use during exercise and check tiny molecules in the blood called microRNAs. They hope to find patterns that could one day help design personalized exercise plans. The study involves 62 adults with heart failure who are starting a cardiac rehab program.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors tailor exercise programs for heart failure patients to get the most benefit.
What could go wrong
This is a small, early-stage observational study. It may not find clear links between blood markers and exercise response, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 62 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Heart failure patient with altered left ventricular ejection fraction

Ages

40 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Heart failure with reduced ejection fraction \< 40% * NYHA functional class ≥ II * Clinically stable for at least 6 weeks * On optimized medical therapy for at least 6 weeks * Prescription for phase II cardiac rehabilitation * BMI between 20-30 kg·m-² * Physical activity level: sedentary or physically active but untrained * Signed informed consent to participate in the study * Affiliation to the French national health insurance system Exclusion Criteria: * Contraindication to regular adapted physical activity * Uncontrolled arterial hypertension * Secondary respiratory disease such as emphysema or chronic obstructive pulmonary disease (COPD) * Secondary cardiovascular disease * Individuals under legal protection or deprived of liberty * Pregnant or breastfeeding women

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Conditions

The condition(s) this trial relates to.

systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac rehabilitation Exercise adaptations Exercise intervention Exercise intolerance Exercise training Hfref - heart failure with reduced ejection fraction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hospital center of Corbie

    RECRUITING

    Corbie, 80800, France

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