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Zapping the brain while training memory: a new hope for MCI?

NCT ID NCT04246164

Symptom relief Sponsor: Medical College of Wisconsin Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether combining a gentle brain stimulation technique called HD-tDCS with computer-based cognitive training is feasible for people with mild cognitive impairment (MCI). Eight participants completed 15 sessions over three months. The main goal was to see if people would stick with the treatment, not to prove it works. Early results suggest the approach is worth studying further in larger trials.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
high definition transcranial direct current stimulation (HD-tDCS) combined with cognitive training
What this could lead to
If this approach proves feasible and effective in larger trials, it could point toward a non-drug way to slow memory decline in people with mild cognitive impairment.
What could go wrong
This is a very small pilot study with only 8 participants, so results may not apply to everyone. The main goal was feasibility, not proof of benefit, and larger studies are needed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

8 people

The number who actually took part.

Started

Jan 2021

Finished

Feb 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥50-90 years 2. Willing and able to undergo all procedures 3. Retains decisional capacity at initial visit 4. Meets criteria for MCI, amnestic type (Petersen, 2004). Exclusion Criteria: 1. Significant kidney injury requiring hemodialysis 2. Automatic Internal Cardiac Defibrillator (AICD) or Pacemaker 3. Significant congestive heart failure 4. History of clinically significant ischemic or hemorrhagic stroke, or lacune or infarct considered by radiologist likely to cause or contribute significantly to cognitive symptoms 5. History of thalamic lacunar stroke 6. Modified Hachinski Ischemia Score \>4 points 7. History of seizure disorder requiring medication 8. History of brain surgery (for seizure disorder, aneurysms, or benign/malignant tumor) 9. History of HIV/AIDS 10. Severe untreated obstructive sleep apnea 11. Greater than three servings alcohol daily or illicit drug use 12. Major neurologic disorders other than dementia (e.g., MS, ALS) 13. Schizophrenia, bipolar disorder, other serious mental illnesses 14. Other significant medical conditions at investigators' discretion 15. Pregnancy 16. Lack of study partner (Participants are allowed to find a new study partner if the original study partner withdraws)

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Conditions

The condition(s) this trial relates to.

cognitive disorder Cognitive Dysfunction Memory Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Memory disorders Memory loss Mild cognitive impairment

Contacts and locations

Locations

  • The Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.