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Simple leg exercises may tighten loose knees in Ehlers-Danlos syndrome

NCT ID NCT07626957

Symptom relief Sponsor: University of Calgary Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a 12-week program of hamstring strengthening exercises can reduce knee looseness and pain in people with hypermobile Ehlers-Danlos syndrome (hEDS) or hypermobility spectrum disorders (HSD). Twenty participants will attend two supervised exercise classes per week and undergo regular knee testing. The goal is to see if this type of exercise is both feasible and effective for improving joint stability.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Progressive resistance exercise focusing on eccentric hamstring loading
What this could lead to
If it works, this could point toward a simple exercise program to improve knee stability and reduce pain for people with HSD/hEDS.
What could go wrong
This is a very small early study with only 20 participants, so results may not apply to everyone. It also excludes people with daily knee pain or prior knee injuries, limiting who can benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Reported diagnosis of HSD or hEDS by a physician * Meet the 2017 International Diagnostic Criteria for HSD and hEDS * Clearance to participant in exercise participation, determined using the Get Active Questionnaire Exclusion Criteria: * Other acquired or hereditary connective tissue disorder (i.e., rheumatoid arthritis, Marfan syndrome, etc.) * Currently experiencing daily knee pain * Prior knee injury or surgery * Intra-articular knee injection in the last 12 months * Currently pregnant

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Conditions

The condition(s) this trial relates to.

Ehlers-Danlos syndrome Ehlers-Danlos syndrome, hypermobility type hypermobility spectrum disorder Joint Instability Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypermobile eds (HEDS) Hypermobile Ehlers-Danlos syndrome Hypermobile spectrum disorder Hypermobility type Ehlers-Danlos syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Calgary - Foothills Campus

    Calgary, Alberta, T2N 4N1, Canada

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