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New gut cleaner could make colon surgery safer

NCT ID NCT07180615

Disease control Sponsor: Universität Luzern Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether a gut-cleaning routine using rifaximin works as well as the standard neomycin/metronidazole combination to prevent infections after colon surgery. About 458 adults having planned colon surgery will take one of the two treatments the day before surgery. Researchers will track infections, deaths, and hospital stay length for 30 days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Rifaximin (Xifaxan) or Neomycin/Metronidazole
What this could lead to
If it works, this could offer a simpler, better-tolerated gut-cleaning option before colon surgery to reduce infection risk.
What could go wrong
This is a phase 4 trial comparing two established drugs, so major surprises are unlikely. The main risk is that rifaximin may not prevent infections as effectively as the standard combination.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 458 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Jun 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * aged ≥ 18 years * undergoind planned colon surgery * colon surgery will be included in Swissnoso SSI surveillance * informed consent Exclusion Criteria: * contraindications and/or intolerance to one of the study compounds * patients with underlying active infection (wound contamination class IV) at the timepoint of incision * pregnant women * unable to follow study protocol

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Conditions

The condition(s) this trial relates to.

Surgical Wound Infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colon surgery Surgical site infection Surgical site infections

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Kantonsspital Aarau

    Aarau, 5001, Switzerland

  • Kantonsspital St. Gallen

    Sankt Gallen, 9007, Switzerland

  • Luzerner Kantonsspital

    Lucerne, 6006, Switzerland

  • Stadtspital Triemli

    Zurich, 8063, Switzerland

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Other studies related to the condition(s) this trial covers.