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New combo treatment may stop gum grafts from shrinking

NCT ID NCT07303192

Symptom relief Sponsor: Kahramanmaras Sutcu Imam University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding injectable platelet-rich fibrin (i-PRF) and low-level laser therapy to standard gum graft surgery could reduce the amount the graft shrinks during healing. Gum grafts are used to cover exposed tooth roots, but they often shrink over time. The study involved 48 healthy adults with gum recession on lower front teeth. Results showed that both i-PRF and laser therapy helped maintain graft size and improve root coverage compared to surgery alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

48 people

The number who actually took part.

Started

Jul 2024

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 18 years. * Systemically healthy. * Cairo Class I gingival recession in vital mandibular anterior incisors. * No caries or restorations in the relevant teeth. * Keratinized gingiva height \< 2 mm in the included teeth. * Plaque Index (PI) \< 1. * Gingival Index (GI) \< 1. Exclusion Criteria: * Active periodontal disease or probing depth \> 3 mm. * Use of medications that could prevent surgery or affect wound healing. * Pregnancy or breastfeeding. * History of periodontal surgery in the working area. * Active smokers. * Current orthodontic treatment.

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Conditions

The condition(s) this trial relates to.

gingival recession

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingival recession, localized Graft shrinkage

Contacts and locations

Locations

  • Kahramanmaraş Sütçü İmam University

    Kahramanmaraş, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.