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Could a simple supplement soothe gulf war Veterans' gut woes?

NCT ID NCT05972291

Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 20, 2026 · Updated 3 times

Summary

This study tests whether taking oral glutamine, a dietary supplement, three times a day for 12 weeks can reduce chronic stomach pain, bloating, and diarrhea in veterans with Gulf War Illness. Researchers will also check if it helps repair the gut lining. The trial involves 80 veterans and compares glutamine to a placebo (whey protein).

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
oral glutamine (a dietary supplement)
What this could lead to
If it works, this could point toward a simple, safe supplement to relieve chronic gut problems in veterans with Gulf War Illness.
What could go wrong
This is a small, early-stage trial (80 people) testing a supplement, not a drug. Results may not apply to all veterans, and the benefit may be no better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2023

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Veterans 18-65 years old with GWI and chronic GI symptoms (abdominal pain, diarrhea, bloating) that started during their deployment in the Persian Gulf 2. Veterans 18-65 years old with GWI and chronic GI symptoms (abdominal pain, diarrhea, bloating) 3. increased intestinal permeability on the lactulose/mannitol permeability test (ratio \>0.07) 4. able and willing to cooperate with the study Exclusion Criteria: 1. current participation in another research protocol or unable to give informed consent 2. women with a positive urine pregnancy test or breastfeeding 3. history of inflammatory bowel disease, lactose intolerance and/or celiac sprue 4. \+ hydrogen breath test for bacterial overgrowth 5. \+ anti-endomysial antibody titer 6. use of NSAIDs 2 weeks before or during the study 7. known allergy to glutamine or whey protein 8. abdominal surgery except for removal of gallbladder, uterus, or appendix \>6 months prior to entry into the study 9. Abnormal serum BUN and/or creatinine 10. Mannitol recovery out of the normal range of 5-25 U/g 11. history of kidney disease 12. allergies to monosodium glutamate 13. current use of anti-seizure medications

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Conditions

The condition(s) this trial relates to.

irritable bowel syndrome persian gulf syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gastrointestinal symptoms Gulf war illness Irritable bowel syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Memphis VA Medical Center, Memphis, TN

    RECRUITING

    Memphis, Tennessee, 38104-2127, United States

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