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Viruses that eat bacteria: can phages quiet a troubled gut?

NCT ID NCT07816809

Symptom relief Sponsor: Colorado State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Researchers are testing two bacteriophage supplements against a placebo in 40 adults with mild to moderate gut symptoms. Bacteriophages are viruses that infect specific bacteria, and these products target strains of E. coli and S. aureus. Over four weeks, the team measures changes in gut symptoms and skin quality to see whether the phages shift the microbiome toward better health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bacteriophage dietary supplements targeting E. coli and S. aureus
What this could lead to
If the phages work, this could point toward a new way to ease bloating, constipation, diarrhea, and skin problems by trimming specific gut bacteria.
What could go wrong
The study is small and early, so the results may not hold up in larger groups. Phages can also fail to survive digestion or fail to change symptoms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Between 18-75 years old * BMI \<30 * Experiencing mild-moderate gastrointestinal distress/ abdominal pain, bloating, constipation, and/or diarrhea Exclusion Criteria: * Younger than 18 years old or greater than 75 years old * BMI \>29.9 * Antibiotic use in the past 2 months * Use of statins, metformin, prescription NSAIDs, and MAO inhibitors, or other medications that could interfere with study outcomes, as determined by the study PI * Current diagnosis of cancer, liver or kidney disease, gastrointestinal diseases, or cardiometabolic disease (diabetes, cardiovascular disease) * Individuals with allergies to capsule ingredients * Pregnant or breastfeeding individuals * Excess alcohol consumption (≥4 drinks on any given occasion and/or ≥8 drinks/week for women, and ≥5 drinks on any given occasion and/or ≥15 drinks/week for men) * Use of dietary supplements that contain probiotics or phages * Actively trying to lose weight * Participation in other research studies that would interfere with study endpoints or compliance * Unable or unwilling to consume capsules, provide stool or blood samples, track bowel movements and symptoms, and attend scheduled clinic visits

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gastrointestinal symptoms Skin quality

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Colorado State University

    RECRUITING

    Fort Collins, Colorado, 80523, United States

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