Can a probiotic stop UTIs from coming back? new study investigates
NCT ID NCT07234227
First seen Jun 25, 2026 · Last updated Aug 28, 2026 · Updated 2 times
Summary
This study tests a vaginal probiotic containing Lactobacillus crispatus, a 'good' bacteria, in women with recurrent urinary tract infections (UTIs). Over 150 participants will use the probiotic for 3 months, and researchers will measure how well the bacteria colonize the vagina and urine. The goal is to understand if this approach can help restore a healthy microbiome and potentially reduce UTI risk.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Lactobacillus crispatus probiotic (vaginal insert)
- What this could lead to
- If successful, this could point toward a simple probiotic treatment to prevent recurrent UTIs by restoring healthy vaginal and urinary bacteria.
- What could go wrong
- This is an early Phase 1 study focused on bacterial colonization, not on preventing UTIs directly. The probiotic may not colonize effectively or reduce infections, and results may not apply to all women.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Expected to start
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Dec 2026
An estimate. Start dates often move.
- Expected to finish
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Feb 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria * English-speaking * ≥ 18 years of age * Diagnosed with recurrent urinary tract infections (UTIs). Specifically, participants will have had 3 UTIs over the past 12 months or 2 UTIs over the past 6 months. At least one of these UTIs must be culture-proven. For UTIs to count for this study, if not culture-proven they must involve the onset of UTI-related symptoms (dysuria, urgency, frequency, suprapubic pain, or urinary changes, etc) with prescription of antibiotics directed at UTI treatment. Exclusion Criteria * Chronically self-catheterize. * Currently use of a vaginal pessary. * Have used a vaginal probiotic in the prior 3 months. * Are pregnant or within 1 year postpartum. * Have poorly controlled diabetes with an A1c of 9 or greater. * Are considered immunocompromised * Are unable to personally provide legal consent
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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