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Could a Parkinson's drug ease radiation brain damage?

NCT ID NCT07125222

Symptom relief Sponsor: Weill Medical College of Cornell University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This trial tests whether Gocovri, an extended-release form of amantadine, can reduce disability and improve cognitive function in adults who have brain damage from radiation therapy. Participants take the drug daily for about 24 weeks, with the dose increasing after the first month. The study measures changes in disability using the Disability Rating Scale and cognition using the Montreal Cognitive Assessment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Gocovri (extended-release amantadine)
What this could lead to
If effective, Gocovri could offer a new way to reduce disability and improve thinking in people with brain damage from radiation therapy.
What could go wrong
This is a small, early-phase trial, so results may not hold up in larger studies. The drug may also cause side effects, and not everyone may benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Aug 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals ≥ 18 years of age. * Individuals with caregivers who are able to complete survey assessments for this study. * Prior brain radiation treatment. * Evidence of moderate-severe confluent white matter hyperintensity on MRI brain scan as judged by neuroradiology impression 0-5 years prior to enrollment. * DRS \> 6 * The effects of Gocovri on the developing human fetus are unknown. For this reason, women of child-bearing potential and men must agree to use adequate contraception (e.g. hormonal or barrier method of birth control) prior to study entry and for the duration of study participation; female subjects will be required to demonstrate a negative urine pregnancy test prior to study entry and subjects who are lactating should be excluded. Exclusion Criteria: * Pregnant or breastfeeding. * Patients with growing brain lesions or those requiring escalating doses of tumor-directed treatment.. * Patients requiring doses of Dexamethasone higher than 4 mg or escalating doses of Dexamethasone * Patients taking Amantadine or with prior usage of Amantadine. * Patients taking other dopaminergic, GABAergic, glutamatergic, or noradrenergic drugs. * Patients with a history of suicidality and depression. * Patients with end stage renal disease (creatinine clearance less than 15 mL/min/1.73 m2).

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Conditions

The condition(s) this trial relates to.

brain disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Encephalopathy Radiation effect

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Weill Cornell Medicine

    New York, New York, 10065, United States

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