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Hormone pretreatment may boost IVF success in stubborn uterine infection

NCT ID NCT07642700

Disease control Sponsor: Guoxia Yang Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether giving a GnRH agonist hormone treatment before a frozen embryo transfer can improve pregnancy and live birth rates in women with persistent chronic endometritis (a uterine infection that doesn't clear with antibiotics). About 150 women aged 20-40 will be followed to compare outcomes between those who receive the hormone pretreatment and those who don't. The goal is to find a better way to prepare the uterus for embryo implantation in this hard-to-treat condition.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This prospective cohort study enrolls infertile patients diagnosed with persistent chronic endometritis who receive FET in reproductive center. Subjects are allocated into two groups: down-regulation endometrial preparation group and conventional artificial cycle or natural cycle group. We compare implantation, clinical pregnancy, miscarriage and live birth rates between two regimens.

Ages

20 to 40 years

Sex

Female participants only

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 20-40 years; confirmed persistent chronic endometritis (PCE) via hysteroscopy plus CD138 immunohistochemistry, defined as positive endometrial pathology after two-course antibiotic treatment for CE. * Frozen-thawed embryo transfer (FET) with available transferable cleavage-stage or blastocyst embryos from IVF/ICSI cycles. * No acute pelvic infection at enrollment; ≥1 month elapsed after completion of last antibiotic therapy for endometritis. * Normal uterine cavity except for inflammatory changes of PCE; no severe uterine malformation or severe intrauterine adhesion requiring surgical intervention. * Voluntarily sign informed consent and complete full follow-up of pregnancy outcomes Exclusion Criteria: * History of pelvic tuberculosis, intrauterine adhesions, submucous uterine myoma or endometrial polyp before FET * Uncontrolled systemic endocrine disorders, autoimmune diseases (APS, SLE), severe hepatic/renal/cardiopulmonary dysfunction. * Known allergy to GnRH agonist for down-regulation regimen; prior long-acting GnRH-a intolerance. * Recent use of immunosuppressant, long-term glucocorticoid or drugs interfering endometrial development within 3 months before enrollment. * Lost to follow-up or plan to abandon embryo transfer after enrollment.

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Conditions

The condition(s) this trial relates to.

chronic endometritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic endometritis

How to take part

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  1. The official record

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More trials for these conditions

Other studies related to the condition(s) this trial covers.