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Can ginkgo biloba boost brain power after a stroke?

NCT ID NCT07220538

Symptom relief Sponsor: Dr. Willmar Schwabe GmbH & Co. KG Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 09, 2026 · Updated 3 times

Summary

This study tests whether ginkgo biloba tablets can help improve memory and thinking in people aged 55 and older who recently had a mild stroke. 400 participants will either take ginkgo biloba plus standard care or standard care alone for 12 months. Researchers will measure changes in cognitive tests and track any new strokes or side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ginkgo biloba leaf extract
What this could lead to
If it works, this could provide a safe, add-on option to help improve memory and thinking in older adults after a stroke.
What could go wrong
This is a phase 4 trial, but ginkgo biloba has shown mixed results in past studies. The effect may be small or not clinically meaningful.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 400 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

55 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Male and female participants aged ≥ 55 years who gave their informed consent. 2. Non-disabling overt acute ischemic stroke (NIHSS (National Institutes of Health Stroke Scale) ≤ 5, mRS (Modified Rankin Scale) ≤ 2 at the day of screening) confirmed by magnetic resonance imaging, and at least 7 but no longer than 14 days before baseline. 3. Cognitive impairment (MoCA (Montreal Cognitive Assessment)) total score (corrected) \< 23 for participants with up to 12 years of education, or MoCA total score \< 22 if more than 12 years of education). 4. Sufficient Chinese language skills to understand and respond to all interview questions, complete questionnaires and undergo neuropsychological testing. Exclusion Criteria: 1. Participation in another experimental drug trial at the same time or within the past 4 weeks before enrollment. 2. Aphasia, dysarthria, apraxia or paresis of the dominant upper extremity, severe and insufficiently corrected loss of vision or hearing, severe language difficulties or any other disability that may prevent the participant from cooperating adequately in the trial or that may interfere with neuropsychological test performance. 3. Pre-stroke cognitive impairment (16-item Informant Questionnaire on Cognitive Decline (IQCODE) score ≥ 3.3), preexisting major neurocognitive disorder (e. g., dementia due to Alzheimer's disease, vascular dementia, dementia with Lewy bodies, frontotemporal dementia). 4. Cardiogenic ischemic stroke, atrial fibrillation, or any other conditions that require the intake of anticoagulants. 5. Conditions that require the administration of thrombolytics at day of Screening or Visit 1. 6. Index acute ischemic stroke with hemorrhagic transformation. 7. Intake of traditional Chinese medicines. 8. Major neurological disorder, including intracranial hemorrhage, delirium, Parkinson's disease, brain tumor, alcohol-associated brain damage, infectious CNS disease, epilepsy, recent brain trauma, subdural hematoma, HIV-associated cognitive disorder, Huntington's disease, Pick's disease, Wilson's disease, normal pressure hydrocephalus, hydrocephalus, progressive supra-nuclear palsy, Creutzfeldt-Jakob disease, etc. 9. Major depression or generalized anxiety disorder. 10. Active malignant disease. 11. Alcohol addiction or substance abuse. 12. Known hypersensitivity to Ginkgo biloba, Ginkgo biloba extract or any ingredient of the drug under trial. 13. Any circumstances that prevent the participant to be followed up at the scheduled intervals. Hospitalization of the participant for long-term treatment or nursing home placement for bedside care (assisted living facility residence or stay in a rehabilitation facility is acceptable if the participant is not bedridden and does not need general bedside nursing, and if an informant is available who sees the participant on a regular basis and accompanies him/her to the trial visits). 14. Severe comorbidity with life expectancy \< 12 months.

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Conditions

The condition(s) this trial relates to.

cognitive disorder Cognitive Dysfunction ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Impairment, cognitive Ischemic stroke hospitalized

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    37 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Affiliated Hospital of Chifeng University

    ACTIVE_NOT_RECRUITING

    Chifeng, China

  • Affiliated Hospital of Hebei University

    RECRUITING

    Hebei, China

  • Affiliated Zhongshan Hospital of Dalian University

    RECRUITING

    Dalian, China

  • Baotou Central Hospital

    RECRUITING

    Baotou, China

  • Beipiao Central Hospital

    RECRUITING

    Beipiao, China

  • Benxi Central Hospital

    RECRUITING

    Benxi, China

  • Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital)

    RECRUITING

    Dalian, China

  • China-Japan Union Hospital of Jilin University

    RECRUITING

    Jilin City, China

  • Dalian Lvshunkou District Traditional Chinese Medicine Hospital

    RECRUITING

    Dalian, China

  • Dalian University Affiliated Xinhua Hospital

    RECRUITING

    Dalian, China

  • First Hospital of Shanxi Medical University

    ACTIVE_NOT_RECRUITING

    Shanxi, China

  • Hainan General Hospital

    RECRUITING

    Hainan, China

  • Hengshui People's Hospital (Harrison International Peace Hospital)

    RECRUITING

    Hengshui, China

  • Huizhou First Hospital

    RECRUITING

    Huizhou, China

  • Jiujiang No.1 People's Hospital

    RECRUITING

    Jiujiang, China

  • Liaocheng People´s Hospital

    RECRUITING

    Liaocheng, China

  • Liuzhou Workers´ Hospital

    RECRUITING

    Liuzhou, China

  • Luoyang Central Hospital

    RECRUITING

    Luoyang, China

  • Nanning First People's Hospital

    RECRUITING

    Nanning, China

  • Puyang Oilfield General Hospital

    RECRUITING

    Pujiang, China

  • Qilu Hospital of Shandong University

    RECRUITING

    Qingdao, China

  • Second Hospital of Shanxi Medical University

    RECRUITING

    Shanxi, China

  • Shanxi Cardiovascular Hospital

    RECRUITING

    Shanxi, China

  • Siping City Central People's Hospital

    RECRUITING

    Siping, China

  • Suining Central Hospital

    RECRUITING

    Suining, China

  • The 2nd Affiliated Hospital of Harbin Medical University

    RECRUITING

    Harbin, China

  • The First Affiliated Hospital of Jiamusi University

    RECRUITING

    Jiamusi, China

  • The First People's Hospital Of Shenyang

    RECRUITING

    Shenyang, China

  • The First People's Hospital of Chenzhou

    RECRUITING

    Chenzhou, China

  • The People's Hospital of Anyang City

    RECRUITING

    Anyang, China

  • The People's Hospital of Liaoning Province

    RECRUITING

    Shenyang, China

  • The Second Affiliated Hospital of Henan University of Science and Technology

    RECRUITING

    Henan, China

  • The Second Hospital of Hebei Medical University

    RECRUITING

    Hebei, China

  • Tiantan Hospital

    RECRUITING

    Beijing, China

  • Weifang People´s Hospiztal

    RECRUITING

    Weifang, China

  • Wuxi No.2 People's Hospital

    RECRUITING

    Wuxi, China

  • Yantaishan Hospital

    RECRUITING

    Yantai, China

  • Zhongnan Hospital of Wuhan University

    ACTIVE_NOT_RECRUITING

    Wuhan, China

  • Zhumadian Central Hospital

    RECRUITING

    Zhumadian, China

  • Zibo Municipal Hospital

    RECRUITING

    Zibo, China

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