Can a Team-Based tech approach boost quality of life in older cancer patients?
NCT ID NCT05720910
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new way of organizing care for people aged 70 and older who have cancer (breast, lung, colorectal, or prostate) plus at least one other serious health condition. The GERONTE program brings all their doctors and nurses together using a shared digital care plan. Researchers want to see if this improves patients' quality of life after 6 months compared to usual care. About 720 patients from 8 hospitals in France are taking part.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- coordinated care pathway (GERONTE)
- What this could lead to
- If successful, this could show that a team-based, technology-supported care plan improves quality of life for older adults with cancer and multiple health issues.
- What could go wrong
- This is a study testing a care process, not a new drug or treatment. It may not show a clear benefit, and results may not apply to all hospitals or patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 720 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Oct 2024
- Expected to finish
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Apr 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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70 to 130 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: \- General inclusion criteria 1. Age ≥ 70 years old. 2. New or progressive cancer (breast, lung, colorectal, prostate), histologically proven or strong clinical suspicion, fulfilling the tumor specific criteria. 3. Estimated life expectancy greater than 6 months. 4. At least one moderate/severe multimorbidity inclusion criteria other than current cancer (see separate list under 5.3). 5. Patients must be willing and able to comply with study procedures. 6. Voluntarily signed and dated written informed consents prior to any study specific procedure. 7. QLQ-C30 Quality of Life Questionnaire fully completed at baseline, before inclusion. 8. Patients affiliated with a French social security scheme in accordance with the French law on biomedical research (Article 1121-11 of the French Code of Public health). Tumor specific inclusion criteria 9. Specific inclusion criteria for breast cancer: 9.1. Non-metastatic breast cancer (M0): \- No prior treatment for the current breast cancer. \- All 3 criteria required: o Clinical staging: cT2-3-4 Nany, or cTany N1-2-3; * The cancer specialist considers\* surgery; * The cancer specialist considers\* radiotherapy and/or chemotherapy. 9.2. Metastatic breast cancer (M1): Both criteria required: * The cancer specialist considers\* chemotherapy or PARP-inhibitors or mTOR-inhibitors / PIK3CA inhibitors; Previous endocrine therapy +/- CDK4/6 inhibitors is allowed; * The patient received maximum 1 prior line of chemotherapy for metastatic disease. * 'consider' implies that this treatment may be a treatment option for this patient in this particular setting. If at a later point, a different treatment choice is made, the patient remains eligible. 10. Specific inclusion criteria for colorectal cancer: 10.1. Non-metastatic colorectal cancer (M0): \- No prior therapy for the current tumor in the recruiting hospital * At least one of the 3 criteria required: o The cancer specialist considers\* surgery; * The cancer specialist considers\* radiotherapy; * The cancer specialist considers\* chemotherapy and/or immunotherapy. 10.2. Metastatic colorectal cancer (M1): * The cancer specialist considers\* first or second line systemic therapy and/or radiotherapy (+/- surgery). No previous chemotherapy allowed except adjuvant/perioperative chemotherapy stopped for more than 12 months. * 'consider' implies that this treatment may be a treatment option for this patient in this particular setting. If at a later point, a different treatment choice is made, the patient remains eligible. 11. Specific inclusion criteria for lung cancer: 11.1. Non-metastatic lung cancer (M0): * No prior therapy for the current tumor in the recruiting hospital * At least one of the 3 criteria required: * The cancer specialist considers\* surgery (patients considered for treatment with percutaneous thermoablation alone are not eligible); * The cancer specialist considers\* radiotherapy (except SBRT); * The cancer specialist considers\* systemic therapy. Possible systemic therapies are chemotherapy and/or immune therapy and/or targeted therapy. Patients only considered\* for monotherapy with anti-EGFR TKI or somatostatin analog are not eligible. 11.2. Metastatic lung cancer (M1): * The cancer specialist considers\* first or second line systemic therapy. Possible systemic therapies are chemotherapy and/or immune therapy and/or targeted therapy. Patients only considered\* for monotherapy with anti-EGFR TKI or somatostatin analog are not eligible. \*'consider' implies that this treatment may be a treatment option for this patient in this particular setting. If at a later point, a different treatment choice is made, the patient remains eligible. 12\. Specific inclusion criteria for prostate cancer: 12.1. Non-metastatic prostate cancer (M0): one of the following: * First diagnosis M0 prostate cancer (no therapy received yet for prostate cancer): at least one of the 2 criteria required: o The cancer specialist considers\* radiotherapy; o The cancer specialist considers\* hormone therapy (ADT +/- combination Abiraterone and Prednisone). * Salvage treatment M0 prostate cancer (received prior surgery at least 6 months before): o The cancer specialist considers\* radiotherapy (+/- ADT) * Non-metastatic castration resistant prostate cancer: * The cancer specialist considers\* treatment intensification (ADT + Enzalutamide or Apalutamide or Darolutamide). 12.2. Metastatic prostate cancer (M1): - The cancer specialist considers\* treatment with Abiraterone or Enzalutamide or Apalutamide, or Docetaxel or Cabazitaxel or PARP-inhibitors or Lutetium PSMA. \*'consider' implies that this treatment may be a treatment option for this patient in this particular setting. If at a later point, a different treatment choice is made, the patient remains eligible. Exclusion Criteria: 1. Mental illness/cognitive impairment that limits ability to provide consent or complete trial procedures. 2. Participating to an interventional clinical trial with a non-registered anticancer drug or to another geriatric intervention trial. 3. Patients and caregivers are unable or unwilling to use ICT-devices (tablet,computer, smartphone) or the Internet according to protocol. 4. Patient already included in this study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre Antoine Lacassagne
Nice, 06189, France
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Centre Azuréen de Cancérologie
Mougins, 06250, France
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Centre Eugène Marquis
Rennes, 35042, France
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Centre Hospitalier Départemental Vendée
La Roche-sur-Yon, 85000, France
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Centre Hospitalier Universitaire de Nice
Nice, 06000, France
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Centre Hospitalier de la Côte Basque
Bayonne, 64109, France
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Centre Léon Bérard
Lyon, 69373, France
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Groupe Hospitalier Rance Emeraude
Dinan, 22100, France
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Groupe Hospitalier Rance Emeraude
St-Malo, 35400, France
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Hôpital Tenon AP-HP
Paris, 75020, France
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Institut Bergonié
Bordeaux, 33076, France
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