Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can brain scans and DNA predict teen depression?

NCT ID NCT01743716

Knowledge-focused Sponsor: Mclean Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how mood and brain activity are linked in adolescent girls to find genetic and brain-based clues that might predict depression. One hundred healthy girls aged 12-14 and their mothers took part over six months. The teens completed interviews, questionnaires, computer tasks, and provided saliva for genetic testing, plus an fMRI brain scan. The goal is to better understand what puts some teens at risk for depression.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could help identify early warning signs for depression in teens, leading to better prevention strategies.
What could go wrong
This is an observational study with a small sample of 100 healthy girls, so findings may not apply to everyone. It does not test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

100 people

The number who actually took part.

Started

Apr 2013

Finished

Dec 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study will include two adult and two adolescent cohorts. The adult cohort includes two different groups of mothers: (a) MDD Mothers: Mothers with current or past major depressive disorder and (b) Healthy Control Mothers: Mothers with no history of psychopathology. The female adolescent cohorts are as follows: (c) High Risk Female Adolescents: Healthy female adolescents aged 12-14 with a mother reporting past or current MDD, (d) Healthy Female Adolescents: Healthy female adolescents aged 12-14 with a mother reporting no history of psychopathology.

Ages

12 years and older

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Adult Cohort A. MDD Mothers Cohort Inclusion Criteria: * Current or past Major Depressive Disorder * English as first language or English fluency * Biological daughter who meets inclusion/exclusion criteria for High Risk Female Adolescent B. Healthy Control Mothers Cohort Inclusion Criteria: * No history of psychopathology * English as first language or English fluency * Biological daughter who meets inclusion/exclusion criteria for Healthy Female Adolescent Adolescent Cohort General Inclusion Criteria for Adolescent Cohorts: * Female * Ages 12-14 * English as first language or English fluency * Right handed General Exclusion Criteria for Adolescent Cohorts: * Past or present diagnosis of Major Depressive Disorder * Past or present diagnosis of any anxiety disorder * Past or present diagnosis of Bipolar Disorder * Past or present diagnosis of ADHD * Presence of medical or neurological illness (head injury, loss of consciousness greater than 5 minutes, seizure) * Current use of psychotropic medication * Presence of any contraindication for MRI: * Cardiac pacemakers * Metal clips on blood vessels (also called stents) * Artificial heart valve, artificial arms, hands, legs, etc. * Brain stimulator devices * Implanted drug pumps * Ear or eye implants * Known metal fragments in eyes * Exposure to metal filings or shrapnel (sheet metal workers, welders, and others) * Other metallic surgical hardware in vital area * Certain tattoos with metallic ink * Certain IUDs containing metal * Certain transdermal (skin) patches such as: * NicoDerm (nicotine for tobacco dependence) * Transderm Scop (scopolamine for motion sickness) * Ortho Evra (birth control) * Positive urine pregnancy test C. High Risk Female Adolescent Additional Inclusion Criterion: • Biological daughter of participant in the MDD Mothers cohort D. Healthy Female Adolescent Additional Inclusion Criterion: • Biological daughter of participant in the Healthy Control Mothers cohort

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Major depressive disorder are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Major depressive disorder

Contacts and locations

Locations

  • McLean Hospital

    Belmont, Massachusetts, 02478, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.