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Hand therapy plus gabapentin may ease carpal tunnel pain better than pills alone

NCT ID NCT06778798

Symptom relief Sponsor: Universidad Europea de Madrid Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether adding a specific hand and arm therapy technique (called median nerve neural mobilization) to the pain medication gabapentin could reduce pain more than gabapentin alone in people with carpal tunnel syndrome. 72 adults with confirmed carpal tunnel syndrome took part. The main goal was to measure pain changes using a simple pain scale, and the study also checked how well the hand and arm functioned.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
gabapentin (oral capsules) and median nerve neural mobilization (manual therapy)
What this could lead to
If it works, this could point toward a more effective, non-surgical way to manage carpal tunnel pain by combining medication with physical therapy.
What could go wrong
This is a small, completed Phase 4 trial with only 72 participants, so results may not apply to everyone. The manual therapy technique requires a skilled practitioner, and gabapentin can cause side effects like dizziness or drowsiness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

72 people

The number who actually took part.

Started

Feb 2025

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants must be medically diagnosed with unilateral carpal tunnel syndrome (with confirmative electrodiagnostic findings). * Full understanding of written and spoken Spanish (language). * Participants must freely consent to participate. * The presence of positive Phalen and Tinel signs. * The presence of carpal tunnel syndrome signs and symptoms Exclusion Criteria: * The lack to meet inclusion criterions, the presence of cognitive impairment, tumors, cancer, recent (affected) upper limb surgery or trauma, pregnancy, metabolic neuropathy, obesity (body mass index over 30), participants who are not employed, deformities of the (affected) upper limb, recent skin injuries or infections (in the affected upper limb), autoimmune inflammatory conditions or flu type symptoms, allergy to gabapentin, allergy to ibuprofen arginine, and also: participants must not be (during the present investigation) under any type of pain reducing treatment (conservative, homeopathic, invasive or not invasive)

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Conditions

The condition(s) this trial relates to.

carpal tunnel syndrome Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carpal tunnel syndrome

Contacts and locations

Locations

  • Ciudad Hospitalaria Enrique Tejera

    Valencia, Carabobo, 02001, Venezuela

More trials for these conditions

Other studies related to the condition(s) this trial covers.