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Does mixing numbing agent into steroid shots ease hand pain?

NCT ID NCT04253457

Symptom relief Sponsor: University Hospital Plymouth NHS Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time

Summary

Doctors often treat trigger finger, de Quervain's tenosynovitis, and carpal tunnel syndrome with steroid injections. Some mix in a local anaesthetic to reduce pain after the shot, while others do not. This trial compares pain levels in adults who receive a steroid injection with or without added local anaesthetic. Researchers measure pain at one hour and over the next 24 hours to see if the mixture makes a difference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
triamcinolone, a corticosteroid, given alone or mixed with a local anaesthetic
What this could lead to
If adding local anaesthetic helps, doctors could keep using it to make steroid shots less painful. If it does not help, the NHS could save time and money by skipping an unnecessary step.
What could go wrong
This is a small trial with 25 people at one hospital, so the results may not apply everywhere. Pain scores right after an injection can vary for many reasons, and the study may not show a clear difference.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

25 people

The number who actually took part.

Started

Feb 2020

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female ages \>/= 18 years * A clinical diagnosis of trigger finger, de Quervains tenosynovitis or carpal tunnel syndrome made by a consultant physician. * Treatment with corticosteroid injection is recommended by the doctor and agreed by the patient * Patient is willing and able to give informed consent for participation in the study Exclusion Criteria: * Previous surgery for the condition being treated at the desired location of injection * Previous steroid injection for the condition being treated at the desired location of injection * Clinical suspicion of local or systematic sepsis or infection * History of hypersensitivity to the corticosteroid or local anaesthetic * Pregnant or breast-feeding females * Unable to understand and complete self-report questionnaires written in English

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Conditions

The condition(s) this trial relates to.

carpal tunnel syndrome de Quervain disease trigger thumb

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carpal tunnel syndrome De quervains tenosynovitis Trigger finger

Contacts and locations

Locations

  • University Hospitals Plymouth NHS Trust

    Plymouth, Devon, PL6 8DH, United Kingdom

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