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Washing the chest with antifungals: a new hope for deadly fungal infections?

NCT ID NCT07337993

Disease control Sponsor: University of Health Sciences Lahore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether washing the chest cavity with the antifungal drug voriconazole can help treat a rare but serious fungal infection of the lung lining. It includes 50 patients who either get the wash before surgery or as a standalone treatment if they are too sick for surgery. The goal is to see if this approach improves lung expansion and reduces complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
voriconazole
What this could lead to
If it works, this could offer a less invasive treatment option for fungal chest infections, especially for patients too sick for surgery.
What could go wrong
This is a small, early study with only 50 participants. It may not show clear benefits, and there are risks like allergic reactions or complications from the procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All age patients with confirmed fungal empyema thoracis. * Patients with adequate pleural drainage through an intercostal chest tube. * Patients receiving systemic antifungal therapy. * Patients either: 1. scheduled for surgical decortication but undergoing lavage as a preoperative adjunct, or 2. considered unfit for surgery and managed conservatively. Exclusion Criteria: * Bacterial empyema without fungal growth. * Known hypersensitivity to anti-fungals. * Severe hepatic impairment (Child-Pugh class C) contraindicating voriconazole. * Pregnancy or lactation. * Refusal to participate.

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Conditions

The condition(s) this trial relates to.

fungal lung infectious disease pleural empyema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fungal infection lungs Pleural empyema Pyothorax

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Services Hospital Lahore

    RECRUITING

    Lahore, Punjab Province, 54000, Pakistan

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