Stomach pain mystery: why do some patients stay sick despite treatment?
NCT ID NCT05513040
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study followed 300 adults with functional dyspepsia (chronic stomach discomfort) who were taking standard medications like acid reducers or antidepressants. The goal was to see which factors—such as anxiety or sleep problems—might predict whether symptoms improve after 6 months. Researchers hope to better understand why 20-50% of patients don't get relief from current treatments.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help doctors identify which patients with functional dyspepsia are less likely to improve with standard medications, allowing for more personalized treatment plans.
- What could go wrong
- This is an observational study, not a test of a new treatment. It only looks at existing medications and cannot prove cause and effect. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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300 people
The number who actually took part.
- Started
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Jun 2022
- Finished
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Jun 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients aged ≥ 18 years old who met criteria of functional dyspepsia defined by Rome IV were eligible for our study.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. age ≥18 years old 2. Patients who met Rome IV criteria 3. Normal upper endoscopy and abdominal ultrasonography within one year Exclusion Criteria: 1. Patients with local or systemic diseases which may cause dyspeptic symptoms: Known active peptic ulcer, cholecystitis, gallstone, gastrointestinal obstruction, gastroparesis, and etc.; Known acute or chronic injury of liver or kidney; Obvious hematological abnormality, or endocrine and metabolic diseases; Known malignancy; Obvious cardiovascular or cerebrovascular diseases (such as coronary heart disease, arrhythmia, cerebral infarction and etc.; Other conditions which may be associated with dyspeptic symptoms (such as NSAIDs associated dyspepsia) 2. organ failure defined by Marshall standard 3. severe psychiatric illnesses 4. known malignancy 5. pregnancy or lactation 6. unable to provide consent 7. suspected or identified bowel obstruction
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Lanzhou University Second Hospital
Lanzhou, Gansu, China
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The Second Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, 710032, China
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Xijing 986 Hospita
Xi'an, Shaanxi, 710032, China
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Xijing Hospital of Digestive Diseases
Xi'an, Shaanxi, 710032, China
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