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Protein shake vs. gut trouble: can whey help athletes digest fructose after heat stress?

NCT ID NCT06648967

Knowledge-focused Sponsor: Arizona State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Jul 24, 2026

Summary

This pilot study tests whether a multi-ingredient whey supplement can reduce fructose malabsorption in healthy adults after hiking under heat stress. Eight participants will consume fructose and have their breath hydrogen measured as a marker of malabsorption, both before and after 3 to 5 weeks of daily protein supplementation. The goal is to better understand exercise-related gut distress, which affects up to 90% of athletes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a multi-ingredient fermented whey supplement
What this could lead to
If it works, this could point toward dietary strategies to reduce exercise-related gut distress in athletes.
What could go wrong
This is a very small pilot study with only 8 participants, so results may not apply broadly. The intervention is a supplement, not a drug, and effects may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

8 people

The number who actually took part.

Started

Oct 2024

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy subjects living in the United States. * Women/Men aged between 18-60 years (50-50%). * BMI value between ≥18.5 and ≤ 30 kg/m2. * No physical limitations (i.e., able to perform all activities associated with daily living in an independent manner). * Written informed consent. * Completed PAR-Q+ without any "yes" responses. * If currently using chronically or intermittently, willing to stop taking pre- and probiotics beginning 1 month prior to and throughout data collection. * If currently using chronically or intermittently, willing to stop using laxatives or fiber supplements, antacids and prokinetics beginning 1 month prior to and throughout data collection. Exclusion Criteria: * Smoking. * Clinical or self-perceived lactose intolerance. * Clinical or self-perceived milk protein allergy. * Diagnosed GI tract disorders or diseases. * Musculoskeletal disorders. * Diagnosed metabolic disorders (such as diabetes). * Use of any medications known to affect protein metabolism (i.e., corticosteroids, non-steroidal anti-inflammatories, or prescribed acne medications). * Chronic use of gastric acid suppressing medication or anti-coagulants. * Chronic use of anti-inflammatory medication. * Unwilling to stop taking pre- and probiotics beginning 1 month prior to and throughout data collection. * Unwilling to stop using laxatives or fiber supplements, antacids and prokinetics beginning 1 month prior to and throughout data collection.

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Conditions

The condition(s) this trial relates to.

malabsorption syndrome multiple endocrine neoplasia type 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Quality of life

Contacts and locations

Locations

  • Health Futures Center

    Phoenix, Arizona, 85054, United States

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Other studies related to the condition(s) this trial covers.