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Sugar and stress: could fructose malabsorption fuel anxiety?

NCT ID NCT05371067

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether difficulty digesting fructose (a sugar found in many foods) is linked to anxiety and changes in gut bacteria. Researchers compared 56 healthy young men who either absorb fructose normally or have trouble absorbing it. The goal was to see if fructose malabsorption affects mood and the gut microbiome, without any treatment being tested.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fructose respiratory test
What this could lead to
If successful, this could point toward dietary strategies for managing anxiety linked to gut health.
What could go wrong
This is a small, completed observational study in healthy young men only, so results may not apply to broader populations or confirm cause and effect.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

56 people

The number who actually took part.

Started

Jun 2021

Finished

May 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy volunteers * Aged 18 to 35 * Male sex * BMI between 18.5 and 25 * Affiliation to a social security scheme * Adult patient having read and understood the information letter and signed the consent form Exclusion Criteria: * Presence of irritable bowel syndrome, celiac disease * Presence of a psychiatric illness * Presence of a neurodegenerative disease * Presence of an eating disorder * Presence of chronic disease, including inflammatory disease * Presence of diabetes * Presence of an acute infectious disease * Presence of a surgical history of the digestive tract (excluding appendectomy) * Taking long-term treatment * Taking antibiotics within 6 months * Taking probiotics within 3 months * Typical diet low in lactose, FODMAP, gluten, vegetarian, vegan, vegan, chromonutrition .... in progress * Smoker * Person deprived of liberty by an administrative or judicial decision or person placed under judicial protection / under guardianship or guardianship * Simultaneous participation in another interventional clinical trial

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • CHU de ROUEN

    Rouen, Rouen, 76000, France

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