Sugar and stress: could fructose malabsorption fuel anxiety?
NCT ID NCT05371067
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether difficulty digesting fructose (a sugar found in many foods) is linked to anxiety and changes in gut bacteria. Researchers compared 56 healthy young men who either absorb fructose normally or have trouble absorbing it. The goal was to see if fructose malabsorption affects mood and the gut microbiome, without any treatment being tested.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- fructose respiratory test
- What this could lead to
- If successful, this could point toward dietary strategies for managing anxiety linked to gut health.
- What could go wrong
- This is a small, completed observational study in healthy young men only, so results may not apply to broader populations or confirm cause and effect.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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56 people
The number who actually took part.
- Started
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Jun 2021
- Finished
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May 2022
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 35 years
- Sex
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Male participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Healthy volunteers * Aged 18 to 35 * Male sex * BMI between 18.5 and 25 * Affiliation to a social security scheme * Adult patient having read and understood the information letter and signed the consent form Exclusion Criteria: * Presence of irritable bowel syndrome, celiac disease * Presence of a psychiatric illness * Presence of a neurodegenerative disease * Presence of an eating disorder * Presence of chronic disease, including inflammatory disease * Presence of diabetes * Presence of an acute infectious disease * Presence of a surgical history of the digestive tract (excluding appendectomy) * Taking long-term treatment * Taking antibiotics within 6 months * Taking probiotics within 3 months * Typical diet low in lactose, FODMAP, gluten, vegetarian, vegan, vegan, chromonutrition .... in progress * Smoker * Person deprived of liberty by an administrative or judicial decision or person placed under judicial protection / under guardianship or guardianship * Simultaneous participation in another interventional clinical trial
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU de ROUEN
Rouen, Rouen, 76000, France
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