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Large study maps genes behind frontotemporal dementia

NCT ID NCT05075187

Knowledge-focused Sponsor: CENTOGENE GmbH Rostock Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study involved over 2,200 people diagnosed with or suspected of having frontotemporal dementia (FTD). Researchers collected blood samples to look for genetic changes linked to the disease. The goal was to find out how common these genetic causes are in people with FTD.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors better understand which genes are linked to frontotemporal dementia, potentially guiding future research and genetic counseling.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly help patients. The results may not apply to all forms of FTD or all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

2,287 people

The number who actually took part.

Started

Sep 2021

Finished

Jan 2024

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants diagnosed with Frontotemporal Dementia (FTD) and participants clinically suspected for FTD

Ages

25 to 85 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Informed consent, which includes reference to the genetic testing, is obtained from the participant/legal guardian * The participant is aged between 25 to 85 years * The participant is diagnosed with Frontotemporal dementia (FTD) or has signs or symptoms of FTD

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Conditions

The condition(s) this trial relates to.

frontotemporal dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Frontotemporal dementia

Contacts and locations

Locations

  • AGZ of Charite Universitätsmedizin Berlin

    Berlin, 12200, Germany

  • AZ Damiaan

    Ostend, West Flanders, 8400, Belgium

  • Asklepios Klinik Nord - Ochsenzoll

    Hamburg, 22419, Germany

  • Azienda Ospedaliera Universitaria Federico II di Napoli

    Naples, 80131, Italy

  • Azienda Ospedaliero-Universitaria di Parma

    Parma, 43126, Italy

  • Azienda USL-IRCCS of Reggio Emilia

    Reggio Emilia, 42121, Italy

  • Baskent University

    Ankara, 06100, Turkey (Türkiye)

  • Bezmialem Vakif University

    Istanbul, 34093, Turkey (Türkiye)

  • CHU de Liege

    Liège, 4000, Belgium

  • CNS - campus neurológico Torres Vedras

    Torres Vedras, 2560-280, Portugal

  • Clinica Universidad de Navarra

    Pamplona, 31008, Spain

  • Gertrudis Klinik

    Leun, Hesse, 35638, Germany

  • Hacettepe University

    Ankara, 06100, Turkey (Türkiye)

  • Hanau Hospital

    Hanau, Hesse, 63450, Germany

  • Hochtaunus-Kliniken gGmbH

    Bad Homburg, 61352, Germany

  • Hospital Beatriz Ângelo

    Loures, 2674-514, Portugal

  • Hospital Clinico San Carlos

    Madrid, 28040, Spain

  • Hospital Garcia de Orta

    Almada, 2805-267, Portugal

  • Hospital Pedro Hispano

    Matosinhos Municipality, 4464-513, Portugal

  • Hospital Universitari vall D´hebron

    Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital da Senhora da Oliveira Guimaraes

    Guimarães, 4835-044, Portugal

  • Istanbul University

    Istanbul, 34080, Turkey (Türkiye)

  • Izmir Economy University Medikalpark Hospital

    Izmir, 35575, Turkey (Türkiye)

  • Koç University Hospital

    Istanbul, 34010, Turkey (Türkiye)

  • Marqués de Valdecilla University Hospital

    Santander, 39011, Spain

  • Mediterraneo Hospital

    Athens, 16675, Greece

  • RWTH Aachen University

    Aachen, 52074, Germany

  • Unidade Psiquiatrica Privada de Coimbra

    Coimbra, 3000-606, Portugal

  • Universitary Hospital La Princesa

    Madrid, 28006, Spain

  • University Hospital Cologne

    Cologne, 50937, Germany

  • University Hospital Dresden

    Dresden, Saxony, 01307, Germany

  • University Hospital Rostock

    Rostock, 18057, Germany

  • University Medical Center Hamburg Eppendorf

    Hamburg, Schleswig-Holstein, 20246, Germany

  • University of Ioannina

    Ioannina, 45110, Greece

  • University of Lübeck

    Lübeck, Schleswig-Holstein, 23562, Germany

  • Università degli studi Gabriele D'Annunzio Chieti-Pescara

    Chieti, 66100, Italy

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