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Diverticulitis dilemma: landmark study to settle surgery debate

NCT ID NCT03994978

Knowledge-focused Sponsor: University Hospital, Basel, Switzerland Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is comparing two approaches for people with recurrent, uncomplicated diverticulitis: elective surgery to remove part of the colon versus conservative (non-surgical) management. The goal is to see which approach leads to better bowel function and quality of life. Researchers will follow 252 participants over time, measuring things like fecal incontinence, constipation, and overall gastrointestinal well-being.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
elective sigmoidectomy (surgical removal of part of the colon)
What this could lead to
If successful, this trial could provide clear evidence on whether surgery or conservative management is better for bowel function and quality of life in people with recurrent diverticulitis.
What could go wrong
This is an observational study, not a randomized trial, so results may be influenced by patient choice. It is also relatively small (252 participants) and focuses on a specific condition, so findings may not apply broadly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 252 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2019

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with recurrent episodes of diverticulitis with indication of further treatment.The physician decides which therapy (conservative or surgical) will be carried out.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with recurrent uncomplicated diverticulitis and surgical indication for sigmoid resection * Patients with recurrent uncomplicated diverticulitis and non-surgical indication for conservative management * Confirmation of at least one episode of acute uncomplicated diverticulitis in computed tomography Exclusion Criteria: * Patients aged under 18. * Patients unable to understand an informed consent. * Patients with chronic pain disorder. * Patients with sigmoid fistulas * Emergency operations. * Pregnant women or lactation. * Patients with other severe gastrointestinal diseases, such as inflammatory bowel diseases (IBD), carcinoma or immunologic disorders. * Patients unable to perform surgery or high-risk patients according to the American Society of Anesthesiology (ASA 4 grade or higher)

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Conditions

The condition(s) this trial relates to.

diverticulitis of colon

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diverticulitis of sigmoid

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • St. Claraspital Basel

    RECRUITING

    Basel, Switzerland

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