Water pill during kidney stone surgery may flush out more fragments
NCT ID NCT07336485
First seen Jun 27, 2026 · Last updated Aug 19, 2026 · Updated 5 times
Summary
This study tested whether giving a diuretic (furosemide) during flexible ureteroscopy for medium-sized kidney stones (up to 30 mm) reduces leftover stone fragments. 2000 adults were randomly assigned to receive furosemide or standard care. Stone-free status was checked with a CT scan four weeks later. The goal is to see if forced urine production helps clear tiny fragments that might otherwise grow or cause symptoms.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- furosemide (a diuretic, or water pill)
- What this could lead to
- If it works, this could become a standard step during kidney stone surgery to help clear more stone fragments, reducing the need for follow-up procedures.
- What could go wrong
- This is a completed trial, but the results are not yet widely adopted. The benefit may be small or not apply to all stone types or patient groups.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
200 people
The number who actually took part.
- Started
-
Jan 2026
- Finished
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Jul 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patients aged 18 years or older. * Patients who underwent flexible ureteroscopy for renal stones measuring 30 millimeters or less. Exclusion Criteria: * Patients with active urinary tract infection. * Patients with a history of previous open renal surgery or renal trauma. * Patients with contraindications to anesthesia, such as severe cardiac disease, uncontrolled diabetes mellitus, or severe coagulation disorder. * Patients with severe renal impairment, defined as an estimated glomerular filtration rate less than 30 milliliters per minute per 1.73 square meters. * Known Ureteric stricture and pelvi-ureteric junction obstruction * Patients with a single kidney. * Patients with contraindications to furosemide administration. * Patients with congenital renal anomalies.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Ain Shams University Hospitals (Urology Department)
Cairo, Cairo Governorate, 11511, Egypt
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Other studies related to the condition(s) this trial covers.
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