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Sound waves may help chemo reach deadly childhood brain tumors

NCT ID NCT05762419

First seen Feb 01, 2026 · Last updated May 24, 2026 · Updated 17 times

Summary

This early-stage study tests whether focused ultrasound can safely open the blood-brain barrier in children with progressive diffuse midline glioma (DMG), a rare and aggressive brain tumor. The goal is to allow more of the chemotherapy drug etoposide to reach the tumor while reducing side effects. Ten children aged 4 to 21 will receive the treatment, and researchers will monitor safety and whether the barrier opens successfully.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Columbia University Irving Medical Center

    RECRUITING

    New York, New York, 10032, United States

    Contact Email: •••••@•••••

    Contact

Conditions

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