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Can fluoride stop root cavities in seniors? new trial aims to find out

NCT ID NCT05765058

Disease control Sponsor: University of Bern Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether different fluoride treatments—like varnishes, solutions, and mousse—can stop root cavities from getting worse in adults over 44. About 136 participants in Switzerland will use these products at home or get them applied by a dentist twice a year. The goal is to find a simple, non-surgical way to manage root cavities in older people.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fluoride (silver diamine fluoride, sodium fluoride varnish, fluoridated toothpaste, fluoridated tooth mousse)
What this could lead to
If successful, this could show that simple fluoride treatments applied at home or by a dentist can stop root cavities from getting worse in older adults.
What could go wrong
This is a small, early-stage trial (136 people) that hasn't started yet. Results may not apply to everyone, and some treatments may not work better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 136 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 95 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Being resident in the area of the canton Bern, * Age \>44 years, * Three or more root caries * Lesions ICDAS (W1 or W2) on the first premolar, canines and front teeth of the upper and lower jaw, * Written declaration of informed consent, * Capacity to understand questionnaire items related to the compliance of the trial. Exclusion Criteria: * Living in long-term care facilities, prisons, hospitals etc., * Known allergic reaction to oral hygiene products and/or medication and/or dental material previously used in the mouth or pharynx, * Inability to follow the procedures of filling out questionnaires or clinical examination, e.g. physical inability to fill in questionnaires

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Conditions

The condition(s) this trial relates to.

root caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NAF Root caries SDF Tooth mousse

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Zahnmedizinklinik University of Bern, Department of Restorative, Preventive and Paediatric Dentistry

    Bern, 3007, Switzerland

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