Glowing dye could help burn surgeons cut away only the dead tissue
NCT ID NCT05593523
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a fluorescent dye called indocyanine green (ICG) can help surgeons see exactly which parts of a burn wound are dead or inflamed. Up to 100 burn patients will receive the dye and have their wounds imaged with a special camera before and during surgery. The goal is to see if this technique helps surgeons remove only the damaged tissue, which could lead to better healing and fewer surgeries.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Indocyanine green (ICG) dye
- What this could lead to
- If successful, this could lead to a more precise surgical tool to help burn surgeons remove only the dead tissue, potentially improving wound healing and reducing the need for repeat surgeries.
- What could go wrong
- This is an early-stage study with only 100 participants, focused on measuring imaging accuracy, not on proving better outcomes. The dye and device are already FDA-approved for other uses, but their benefit for burn surgery is not yet established.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2023
- Expected to finish
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Mar 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Aim 1: Human subjects with partial thickness burn wounds admitted to the UW Burn Center within 24 hours of burn injury and expected to be admitted for 3 days Aim 2: Human subjects with 1-30% total body surface area (TBSA) deep partial or full thickness burn wounds that require surgery.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * English speaker * Patients with partial thickness indeterminate depth burn wounds that occurred within 24 hours of admission and are expected to require admission for at least 3 days (Aim 1) or with deep partial thickness or full thickness burn wounds that are 1-30% TBSA and will likely require surgery (Aim 2) * Subject understands the study procedures and can provide informed consent to participate in the study and authorization for release of relevant protected health information to the study investigator Exclusion Criteria: * Contraindication to Indocyanine Green (ICG) injection, i.e. previous reaction to ICG (adverse event rate: 1 in 42,000) or Iodine allergy. * Inability to obtain consent * Subject with pre-existing inflammatory diseases or chronically treated before admission to the hospital with steroids or nonsteroidal anti-inflammatory drugs or biologics * Subject with immune deficiency (HIV infection or use of corticosteroids, cytostatic drugs, tetracycline and certain bisphosphonates) * Subject with known or suspected infections or on antibiotic therapy * Subject known or suspected to be pregnant
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Wisconsin
Madison, Wisconsin, 53792, United States
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Other studies related to the condition(s) this trial covers.