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ICU kidney trial aims to find best fluid removal rate

NCT ID NCT05817539

Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two approaches to removing excess fluid in intensive care patients with acute kidney injury who are on dialysis. One group will have fluid removed at a moderate rate to actively reduce fluid buildup, while the other group will have fluid removed slowly to just maintain current levels. The goal is to see which strategy leads to fewer days on life support and better recovery. The trial plans to enroll 250 adults in the ICU.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ultrafiltration (fluid removal) procedure
What this could lead to
If successful, this could establish a safer, more effective way to remove excess fluid in ICU patients on dialysis, potentially reducing time on life support and improving survival.
What could go wrong
This is a moderate-sized early-stage trial, so results may not apply to all ICU patients. Aggressive fluid removal can cause low blood pressure or organ injury, and the benefit over standard care is unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 250 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2023

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Acute kidney injury treated by continuous renal replacement therapy in ICU less than 7 days, 2. At least 1 organ failure during ICU in addition to AKI (mechanical ventilation or oxygen therapy or vascular filling \> 1000ml or vasopressor exposure \> 12 hours), 3. Weight loss of less than 3% since starting a net UF or Cumulative UF net less than 2000ml before inclusion, 4. Norepinephrine \< 0,5 µg/kg/min, 5. Absence of hypoperfusion signs defined by the presence of at least 2 out of 4 criteria: * TRC \> 3s at the finger * Marbrure score \> 2 * Lactate \> 2 mmol/L * ScVO2\< 60%, 6. Fluid overload defined as follows : * fluid overload \> 5% of base weight (based on cumulative fluid balance or a weight gain) and/or * Obvious oedema of the lumbar region or flanks (oedema \> 1cm bucket depth). Exclusion Criteria: 1. Chronic renal failure hemodialyzed before admission to the ICU, 2. Mechanical circulatory support (ECMO, LVAD), 3. Pregnant, child -bearing age or lactating women, 4. Stroke based on the combination of central neurological symptoms (aphasia, hemiplegia, hemiparesis) associated with compatible brain imaging, less than 30 days, 5. Intestinal ischemia less than 7 days documented non-operated, 6. Interventional study participation or exclusion period on going,that may interfere with the present study 7. Guardianship, curatorship or safeguard of justice, 8. Absence of signature of free and informed consent by the patient and/or relative, 9. Patients not affiliated to a social security scheme or beneficiaries of a similar scheme

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Conditions

The condition(s) this trial relates to.

acute kidney injury Edema

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute kidney injury Fluid overload

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    14 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CHU Amiens-Picardie

    NOT_YET_RECRUITING

    Amiens, 80480, France

  • CHU Caen Normandie

    NOT_YET_RECRUITING

    Caen, 14033, France

  • CHU Lille - Hôpital Roger Salengro

    NOT_YET_RECRUITING

    Lille, 59037, France

  • Centre Hospitalier d'Ajaccio

    NOT_YET_RECRUITING

    Ajaccio, 20090, France

  • Département d'anesthésie réanimation Hôpital Européen Georges Pompidou

    RECRUITING

    Paris, 75015, France

  • GHP Saint Joseph Marie Lannelongue

    NOT_YET_RECRUITING

    Le Plessis-Robinson, 92350, France

  • Hôpital Edouard Herriot

    NOT_YET_RECRUITING

    Lyon, 69437, France

  • Hôpital Edouard Herriot, Groupement Hospitalier Centre

    RECRUITING

    Lyon, 69003, France

  • Hôpital de la Croix Rousse

    NOT_YET_RECRUITING

    Lyon, 69004, France

  • Hôpital de la Croix Rousse

    RECRUITING

    Lyon, 69004, France

  • Hôpitaux de Bradois - CHRU Nancy

    NOT_YET_RECRUITING

    Vandœuvre-lès-Nancy, 54511, France

  • Service d'Anesthesie-Réanimation, Hôpital Louis Pradel, Hospices Civils de Lyon

    RECRUITING

    Bron, 69500, France

  • Service de Réanimation, CHU de Dijon

    RECRUITING

    Dijon, 21000, France

  • Service de Réanimation, Clinique de la Sauvegarde

    RECRUITING

    Lyon, 69009, France

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