New ultrasound test could prevent fluid overload in sick kids on ventilators
NCT ID NCT07494643
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study looks at whether a simple heart ultrasound test can tell doctors if a child with shock needs more IV fluids. It involves 60 children in intensive care who are on ventilators with low air volumes. The test measures changes in blood flow speed in the aorta during breathing. If accurate, it could help avoid giving unnecessary fluids that may cause harm.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could give doctors a reliable, non-invasive way to decide which critically ill children need fluids, reducing unnecessary fluid overload.
- What could go wrong
- This is a small, early diagnostic study (60 children) that only tests accuracy, not outcomes. The measure may not work well enough in real-world settings.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Nov 2025
- Expected to finish
-
Nov 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
0 days to 15 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age between 0 days and 15 years old * Patient hospitalized in a pediatric intensive care unit. * Prescription of a 10ml/kg (±20%) fluid expansion by the physician in charge, as a standard care treatment of circulatory failure (precise indication is up to the physician in charge). * Mechanical ventilation * Tidal volume \< 6ml/kg (±15%) * Fluid responsiveness echocardiographic assessment as of routine care Exclusion Criteria: * Prematurity (corrected gestational age bellow 37 weeks) * Arythmia * Hemodynamic instability making dangerous the delay necessary for any measurement. * Prone position * Impairment of echocardiographic acoustic window * Extracorporeal membrane oxygenation * Respiratory rate (measured) \> 60 cycles per minute (including high frequency oscillation) * Significant breathing movements (high work of breathing, clinically assessed) * Restlessness with desynchronization patient/ventilator * Open chest * Cardiogenic pulmonary oedema * Known intracardiac or vascular shunt * Known hemodynamically significant valvopathy * Opposition to participate expressed by the patient or by a parent or legal guardian
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Circulatory failure (shock) are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
-
The places running it
6 sites. The list below names each one and where it is.
-
The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
-
A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
-
CHU d'Amiens Picardie
RECRUITINGAmiens, France
-
CHU de BORDEAUX
RECRUITINGBordeaux, France
-
CHU de LIMOGES
RECRUITINGLimoges, France
-
CHU de Rouen Normandie
RECRUITINGRouen, France
-
Hôpital Necker-Enfants Malades
RECRUITINGParis, France
-
Hôpital Robert Debré
RECRUITINGParis, France