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Smarter ventilator settings could ease breathing for ICU patients

NCT ID NCT07769307

Disease control Sponsor: Capital Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 17, 2026 · Last updated Aug 18, 2026 · Updated 1 time

Summary

This pilot trial tests whether using a flow index—a simple measurement from the ventilator—to adjust pressure support can better match breathing effort in adult ICU patients who need a ventilator for more than 48 hours. Half the participants will have ventilator support adjusted using this new method, while the other half receives standard adjustments based on tidal volume and breathing rate. The goal is to see if the new method keeps respiratory muscle pressure in a healthy range, potentially reducing strain and improving recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Flow index-guided pressure support titration, a procedure that adjusts ventilator support based on a non-invasive flow index measurement.
What this could lead to
If successful, this could lead to a more precise way to set ventilator support, potentially reducing breathing effort and improving outcomes for ICU patients.
What could go wrong
This is a small pilot study, so results may not be conclusive. The approach may not prove safer or more effective than standard care, and there are risks of respiratory distress or other complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Apr 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (age ≥ 18 years) receiving pressure support ventilation (PSV) * Expected duration of invasive mechanical ventilation \> 48 hours Exclusion Criteria: * Patients who have received PSV for \> 48 hours at the time of screening * Neuromuscular disease, diaphragmatic dysfunction, or central nervous system disease affecting the respiratory center * Incomplete lung or chest wall integrity (e.g., pneumothorax, tracheoesophageal fistula, rib fractures) * Acute respiratory distress syndrome (ARDS) or chronic obstructive pulmonary disease (COPD) * Body mass index (BMI) \> 35 kg/m² * Pregnancy or lactation * Participation in another interventional study or refusal to participate

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mechanical ventilation

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Capital Medical University Beijing Tiantan Hospital

    Beijing, Beijing Municipality, 100070, China

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