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Fermented foods may boost bone health in vegans

NCT ID NCT07645885

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Recruitment status, easiest to join first

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This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
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The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether eating fermented plant-based foods—like sauerkraut, tempeh, and live-culture yogurt—can improve bone health in premenopausal vegan women. Fifty women will eat either fermented or non-fermented foods for 12 weeks, then switch after a break. Researchers will measure bone breakdown markers, gut bacteria, and mineral absorption to see if fermentation helps bones.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fermented plant-based foods (lacto-fermented vegetables, fermented plant-based yogurt with live cultures, and tempeh)
What this could lead to
If it works, this could point toward a dietary strategy to support bone health in vegan women without relying on supplements.
What could go wrong
This is a small, early-stage trial with only 50 participants, so results may not apply to everyone. The effect on actual fractures or long-term bone density is not being measured directly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

28 to 43 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female, aged 28-43years. * Body mass index (BMI) between 18.5 and 24.9 kg/m². * Premenopausal, with regular menstrual cycles. \* * Adherence to a vegan diet for ≥1 year, confirmed by questionnaire. * Willingness to consume both fermented and non-fermented plant-based study foods. * Ability to comply with all study procedures, including run-in, washout, sample collection, and clinic visits. * Signed written and oral informed consent. * Regular menstrual cycles are defined as spontaneous menstrual bleeding occurring every 21-35 days, with cycle-to-cycle variability not exceeding 7-9 days over the prior three months, and bleeding duration of 3-8 days, in the absence of hormonal contraception or endocrine disorders. Exclusion Criteria: * Chronic diseases or conditions affecting bone metabolism (e.g., osteoporosis, thyroid disorders, chronic kidney and liver disease, menstrual cycles disorders affecting bone health, conditions associated with malabsorption). * History of diagnosed eating disorders. * Chronic inflammatory or gastrointestinal diseases (e.g., IBD, celiac disease). * Recent antibiotic use (within 3 months prior to screening). * Use of Vitamin D supplements exceeding 2000 IU/day. * Abnormal DXA results (T-score ≤ -2.5). * Pregnancy, intention to become pregnant, or lactation during the course of the study * Use of hormonal contraceptives. * Use of medications influencing bone metabolism (e.g., glucocorticoids, antiresorptives). * BMI \<18.5 or \>24.9 kg/m². * Known or suspected non-compliance, drug or alcohol abuse * Inability to follow the procedures of the studies, e.g. due to language problems, psychological disorders, dementia, etc. of the participant or anticipated prolonged absence (e.g. extended travel). * Participation in another clinical study within the last 3 months. * Known allergy or intolerance to study foods.

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As listed by the trial registrant

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How to take part

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  1. The places running it

    2 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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  3. A doctor treating you

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Contacts and locations

Locations

  • Swiss Federal Institute of Technology

    Zurich, Canton of Zurich, 8092, Switzerland

  • Third Faculty of Medicine

    Prague, Prague, 100 00, Czechia

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