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Massive fever study aims to uncover hidden germs in rural asia

NCT ID NCT04629053

Knowledge-focused Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is watching 7,200 people with fever in rural areas of Laos, Myanmar, Thailand, and Bangladesh to find out what germs are making them sick and how they recover. Researchers are not giving any new drugs—they are just collecting samples and health information. The goal is to improve future diagnosis and care for fevers in these regions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors better understand which germs cause fevers in these regions, leading to more accurate diagnosis and treatment.
What could go wrong
This is an observational study, so it does not test any new treatment. Results may not apply to other regions or populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 7,200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2022

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients residing in rural areas in Laos, Myanmar, Thailand, the Thai-Myanmar border region, and Bangladesh and presenting with acute febrile illnesses to participating health facilities

Ages

29 days and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. The patient and/or where relevant their parent/guardian/caretaker is willing and able to give informed consent /assent for participation in the study; 2. Aged \> 28 days (day of birth = Day 1); 3. Axillary temperature at presentation (≥ 37.5°C (99.5°F) OR \< 35.5°C (95.9°F)) and no more likely cause than sepsis for hypothermia OR History of fever in the 24 hours prior to presentation; 4. Onset of illness ≤ 14 days Exclusion Criteria: 1. Accident or trauma is the cause for the patient's presentation; 2. Presentation ≤ 3 days after routine immunisations 3. Is currently under follow-up or has been afebrile for less than 72 hours after completion of a follow-up period. 4. The treating healthcare worker's decision is to send the patient home following initial assessment.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute febrile illness

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites in 3 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Building Resources Across Communities (BRAC)

    NOT_YET_RECRUITING

    Dhaka, 1212, Bangladesh

  • Chiangrai Clinical Research Unit (CCRU)

    RECRUITING

    Chiang Rai, 57000, Thailand

  • Laos-Oxford-Mahosot Wellcome Trust Research Unit

    RECRUITING

    Vientiane, 01000, Laos

  • Shoklo Malaria Research Unit

    RECRUITING

    Mae Sot, Changwat Tak, 63110, Thailand

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